Table 3.
Factors associated with RET/PTC or PAX8/PPARγ rearrangements in multivariate analysis
|
RET/PTC or PAX8/PPARγ positive |
RET/PTC or PAX8/PPARγ negative |
|||
|---|---|---|---|---|
| Characteristic | % or mean (SD) | % or mean (SD) | OR | 95% CI |
| I-131 dose, Gy | ||||
| 0.008-<0.4 | 25.0 | 39.5 | 1.00 | Referent |
| 0.4-<0.91 | 25.0 | 23.7 | 1.38 | (0.28, 7.00) |
| 0.91-<1.63 | 25.0 | 10.5 | 2.47 | (0.34, 19.05) |
| 1.63-8.60 | 25.0 | 26.3 | 0.77 | (0.13, 4.13) |
| P trend | 0.0191 | |||
| Oblast of residence | ||||
| Chernihiv | 45.8 | 57.9 | 1.00 | Referent |
| Kyiv | 12.5 | 23.7 | 0.88 | (0.13, 5.13) |
| Zhytomyr | 41.7 | 18.4 | 11.66 | (2.22, 82.52) |
| P heterogeneity | 0.007 | |||
| Age at surgery, yr | 22.6 (4.5) | 25.8 (5.3) | 0.79 | (0.66, 0.91) |
| P trend | 0.001 | |||
| Sex | ||||
| Male | 54.2 | 36.8 | 1.00 | Referent |
| Female | 45.8 | 63.2 | 0.27 | (0.06, 0.96) |
| P | 0.043 |
1
Based on linear quadratic model (dose+dose2).