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. 2013 Apr 9;2013:805497. doi: 10.1155/2013/805497

The Neural Plasticity Theory of Depression: Assessing the Roles of Adult Neurogenesis and PSA-NCAM within the Hippocampus

Steven R Wainwright 1, Liisa A M Galea 1,*
PMCID: PMC3649690  PMID: 23691371

Abstract

Depression is a devastating and prevalent disease, with profound effects on neural structure and function; however the etiology and neuropathology of depression remain poorly understood. Though antidepressant drugs exist, they are not ideal, as only a segment of patients are effectively treated, therapeutic onset is delayed, and the exact mechanism of these drugs remains to be elucidated. Several theories of depression do exist, including modulation of monoaminergic neurotransmission, alterations in neurotrophic factors, and the upregulation of adult hippocampal neurogenesis, and are briefly mentioned in the review. However none of these theories sufficiently explains the pathology and treatment of depression unto itself. Recently, neural plasticity theories of depression have postulated that multiple aspects of brain plasticity, beyond neurogenesis, may bridge the prevailing theories. The term “neural plasticity” encompasses an array of mechanisms, from the birth, survival, migration, and integration of new neurons to neurite outgrowth, synaptogenesis, and the modulation of mature synapses. This review critically assesses the role of adult hippocampal neurogenesis and the cell adhesion molecule, PSA-NCAM (which is known to be involved in many facets of neural plasticity), in depression and antidepressant treatment.

1. Neural Plasticity and Disease

As the fundamental units of the brain, neurons function to integrate and transmit a myriad of signals across vast and complex networks. Neurons by definition are continually forming, eliminating, and modulating (strengthening and weakening) connections in response to the constant flow of information. In mediating and responding to activity, neurons, including their processes and synapses, must be plastic. Thus neural plasticity may then be defined as the ability of neurons and neural elements to adapt in response to intrinsic and extrinsic signals. As such, our ability to process and synthesize information, ultimately producing behavior, is dependent upon this neural plasticity [1]. It is therefore not surprising that dysregulation or disruption of neural plasticity is associated with neuropsychiatric and neurodegenerative disease.

Dynamic processes such as adult neurogenesis, the development of dendritic spines, and synaptic adaptations are included under the umbrella of neural plasticity and are essential to normal functioning. Aberrant neural production, connectivity, or transmission is invariably present under disease states, such as Alzheimer's disease, schizophrenia, or depression [25]. Each aspect of neural plasticity can independently and additively cause or contribute to the disease state. Thus, it is of fundamental importance to elucidate the neurological underpinnings of these disease states at the cellular level, in order to understand etiology and better develop effective treatment.

2. Adult Hippocampal Neurogenesis

Neural stem cells were first identified in the adult brain of rodents more than 50 years ago [6] and are found across a variety of species including humans [7]. Interestingly, the production of new neurons is typically limited to two regions: the subventricular zone, which lines the lateral ventricles and sends new neurons to the olfactory bulb via the rostral migratory stream, and the subgranular zone of the hippocampus [8].

It is important to note that neurogenesis, as defined here, requires the proliferation, survival, and differentiation of newly generated cells into neurons. Any number of internal and/or external factors may independently affect the proliferation of progenitor cells, their differentiation into neurons, or their survival rates [914]. Thus merely identifying cells as having been produced in the adult brain, without further demonstrating that they survive and become neurons, is insufficient to conclude that neurogenesis has occurred.

Although new neurons can be labelled and observed, the exact role of these neurons in the function of the hippocampus remains to be fully elucidated. New neurons produced in the subgranular zone have been associated with a number of functions [15, 16]. There is solid evidence that new hippocampal neurons are selectively and imperatively involved in spatial learning and memory [1720]. New neurons in the hippocampus, perhaps more ambiguously, have also been associated with the etiology and treatment of depression [2123]. Interestingly, the hippocampus is functionally dissociated along the dorsal-ventral axis, wherein the dorsal region plays a larger role in cognitive faculties, while the ventral region is more involved in emotionality [24, 25]. For the purpose this review, however, we will concentrate on the functions of the hippocampus associated with emotionality and stress and refer the reader to reviews that cover the hippocampus' cognitive associations (See: [26, 27]).

3. Cell Adhesion Molecules

Neural plasticity is a complex and varied process; from neural development, the migration of newly generated neurons, dendritic modifications, and synaptic modulation, many proteins facilitate and contribute to the malleability of neural tissue. Cell adhesion molecules (CAMs) are specialized proteins—typically expressed at the cell surface—which are important in synaptic function, synaptic plasticity, and remodeling of neural circuits [28]. The structure and function of CAMs vary widely within the nervous system, and the categorization and function of each CAM protein involved in neural plasticity are beyond the scope of this review (for a more detailed overview see [28, 29]). This review will instead focus on the potential role of a single CAM, the polysialylated form of neural cell adhesion molecule (PSA-NCAM), in the etiology and treatment of depression.

The neural cell adhesion molecule (NCAM) is a member of the immunoglobulin superfamily of cell adhesion molecules and serves to mediate Ca2+-independent cell-cell and cell-extracellular matrix (ECM) interactions [30]. Through homo- and heterophilic interactions, NCAM functions in cell migration, neurite outgrowth and targeting, axonal branching, synaptogenesis, and synaptic plasticity [3032]. Neural plasticity mediated through the NCAM protein is facilitated through posttranslational modifications, the most important and prevalent of which is glycosylation with polysialic acid (PSA) [33]. Polysialic acid is a linear homopolymer of α2,8-linked sialic acid, which bears a negative charge, acting to abate NCAM-NCAM interactions and therefore interfere with cell adhesion [34]. PSA-NCAM serves to regulate cell-cell and cell-ECM interactions during times of plasticity.

In the adult brain PSA-NCAM is expressed on the cell surface of newly generated daughter cells, on neurites during outgrowth and path finding, and at the synapse of mature neurons [30]. The addition of the PSA moiety to NCAM is essential to neural remodelling and synaptic plasticity [10, 35, 36]. Selective cleavage of PSA in the adult brain inhibits activity-induced synaptic plasticity (induction of long-term potentiation (LTP) and long-term depression (LTD)) and alters the normal migration and integration of newly generated neurons within the hippocampus [10, 35], importantly though cleavage of PSA from NCAM does not disrupt normal basal synaptic neurotransmission or alter normal levels of neural proliferation or survival [10, 35]. PSA-NCAM is therefore a particularly interesting protein in that it is one that mediates plasticity at multiple levels, from neural proliferation, integration, differentiation, neuritic outgrowth, synaptogenesis, and modulation of mature synapses.

4. Depression

Depression is a devastating neuropsychiatric disease that is both prevalent—with a lifetime incidence of 20% [37]—and costly, accruing over $83 billion (USD) annually in expense to society in the USA alone [38]. Depression is a spectrum disorder ranging from dysthymia to major depressive disorder (MDD), which also includes seasonal (seasonal affective disorder) and bipolar subtypes; however general symptomology is characterized by a depressed mood and/or anhedonia [39]. The DSM-IV criteria for diagnosis with MDD may include secondary symptoms such as fatigue, insomnia or hypersomnia, changes in body weight, and impaired cognition [39]. Although depression is prevalent and carries a large burden of disease, the pathoetiology of depression is poorly understood. While antidepressant drugs do exist, they are not ideal, as only a segment of patients is effectively treated, and the therapeutic onset is delayed [4042]. Moreover, the exact mechanism of these drugs remains to be elucidated, though several theories do exist. The existing theories of etiology and treatment of depression will be briefly discussed with an aim of integrating and placing neurogenesis and PSA-NCAM related plasticity within the current state of knowledge.

5. Monoamine Theory of Depression

Much of the current understanding of depression has been built upon the serendipitous discovery of the mood-elevating effects of iproniazid, a monoamine oxidase inhibitor (MAOI), during clinical trials for antituberculosis agents in the early 1950s [43, 44]. Around the same time the first tricyclic antidepressant (TCA), imipramine, a drug also known to modulate monoaminergic neurotransmission, was discovered to relieve depressive symptoms [45]. Both compounds enhance monoaminergic neurotransmitters (primarily serotonin and norepinephrine) function in the synapse and therefore acted as a springboard for the rational design of drugs which specifically enhance the transmission of these neuromodulators. Further, these findings resulted in the development of the monoamine hypothesis of depression [46, 47]. The monoamine hypothesis of depression postulates that the pathophysiological basis of depression is due to the deficient activity of monoamines in the central nervous system [48].

While first generation antidepressant drugs can indeed be effective, remission rates still typically remain below 60%, and treatment is associated with potentially severe side effects, causing a third of patients to discontinue treatment [49, 50]. Thus new drugs, such as selective serotonin reuptake inhibitors (SSRIs), have been developed in an attempt to enhance efficacy and reduce the side effects observed with the broader-acting first generation compounds. However, the ability of these newer drugs to alleviate depression is, unfortunately, typically lower than that of MAOIs and TCAs [50]. SSRIs are the primary first line treatment for patients with major depressive disorder (MDD), yet only a third of patients will respond to these drugs following initial treatment [41]. Even in patients that are initially responsive to treatment, up to 57% will have depressive symptoms return due to a loss of drug efficacy [40].

While it is known that antidepressants modify monoaminergic neurotransmission, it is not known how antidepressants exert their therapeutic effects, as the influence on monoamines occurs within hours of treatment, but alleviation of depressive symptoms requires weeks of exposure [5154]. The monoamine theory explains this delayed efficacy of treatment as the time required for the 5-HT1A serotonin autoreceptor to sensitize and normalize serotonergic tone at the synapse [42, 55, 56]. However, disrupting or ablating portions of the serotonergic system fails to induce a depressive phenotype [57], suggesting that the dysregulation of serotonergic neurotransmission is not the only underlying factor in depression. Given the prevalence of treatment-resistant forms of depression and the limited long-term efficacy of current drugs, novel targets are needed for the development of more efficacious pharmacological treatments.

6. Neurogenic Hypothesis of Depression

As noted earlier, neurogenesis in the adult hippocampus is seen across a variety of species, including humans [7]. Adult hippocampal neurogenesis has been hypothesized to play a potentially important role on the pathology and successful treatment of depression. A neurogenic hypothesis of depression has been postulated, which suggests that reduced adult hippocampal neurogenesis may underlie the pathoetiology of depression, while antidepressant efficacy depends on the upregulation of hippocampal neurogenesis [58].

7. Etiology of Depression and Animal Models

As with other neuropsychiatric disorders, depression has a multifaceted and varied etiology, including genetic, epigenetic, and environmental factors. The most prevalent of these factors is stress. Stress is cited as the leading cause of depression by depressed patients [59]. Unipolar depression is associated with abnormal hypothalamic-pituitary adrenal (HPA) axis function such as hypersecretion of cortisol, abnormal diurnal secretion of cortisol resulting in a flattened circadian rhythm and impaired negative feedback [59, 60]. Interestingly, normalization of HPA function is seen after chronic exposure to antidepressants, an effect coincident with, or slightly preceding, behavioural alleviation of depressive symptoms [61]. As such normalization of HPA function has become a major target of novel therapies [59, 62].

Many animal models of depression capitalize on the association of stress and depression; such models have a solid ethological basis. For instance, models using exposure to chronic variable stress (CVS) have shown good face, construct, and predictive validity, making it one of the most commonly used paradigms to model depression [63]. For example, CVS increases immobility in the forced swim test (FST, a putative measure of behavioural despair) [64], reduces sucrose preference (anhedonia) [65], increases novelty-induced hypophagia [21, 64], reduces hippocampal neurogenesis [21, 65], and reduces the expression of proteins associated with neuroplasticity such as PSA-NCAM [66]. Although it is not possible to model all symptoms of depression in rodents, a battery of key endophenotypes can be examined such as anhedonia, body weight changes, behavioural despair, HPA function, and brain alterations (such as reduced hippocampal volume, neurogenesis, and neural plasticity), as have been observed in human patients with depression [67].

8. Stress, Depression, and Reduced Neural Plasticity

The hippocampal formation is an area rich in mineralocorticoid (MRs) and glucocorticoid receptors (GRs). These receptors function in the maintenance of basal HPA tone and in the regulation of negative feedback of glucocorticoid release during a stress response [68]. Given this, it is not surprising that the hippocampus is particularly vulnerable to the effects of stress and depression [69, 70]. Depressed patients have reduced hippocampal volume which varies with the number of episodes and duration of the illness [7173]. Similarly, postmortem studies of hippocampal tissue collected from depressed patients have shown alterations in gray matter density, reductions in neuropil, and decreased hippocampal neurogenesis [22, 23, 7477]. Animal models of depression using exposure to chronic stress demonstrate the same changes in hippocampal structure and show reductions in neural plasticity, including reductions in neurogenesis and the expression of proteins associated with neural plasticity [21, 64, 65, 78]. Chronic stress exposure also reduces dendrite length and complexity [79, 80], spine density [81], and NCAM expression [65] and modifies expression of synaptic SNARE proteins [82] in the hippocampus.

Stabilization of the HPA axis by antidepressants is associated with improved mood scores that either precedes or is coincident with the behavioural alleviation of depressive symptoms in humans [61]. Thus the improvements in negative feedback inhibition of the HPA axis that correspond to improvement in depressive symptoms with antidepressant treatment may be attributable to neural adaptation in limbic structures that regulate feedback inhibition of HPA axis such as the hippocampus. Interestingly chronic antidepressant treatment is seen to reverse the negative effects of stress on hippocampal volume [65, 83], though the exact contribution of neural plastic elements that underlie this enhancement is not fully understood.

9. Neurogenesis in Antidepressant Efficacy

The neurogenic hypothesis of depression is predicated not only on the previous findings that chronic stress decreases hippocampal neurogenesis [21, 65, 84] but also that antidepressant drugs can both prevent [83, 85] and reverse [21, 65, 86] this effect (see Table 1). The enhancement of adult hippocampal neurogenesis is dependent on chronic, but not acute, exposure to antidepressants, occurring in a manner that temporally coincides with the delayed clinical efficacy of these drugs [9, 21]. This delayed enhancement of neurogenesis is mediated through the increased proliferation of neural progenitor cells, while the proportion and the differentiation of surviving cells into neurons remain constant [9]. Several classes of antidepressant including SSRIs, TCAs, MAOIs, SNRIs, and melatonergic antidepressants increase neurogenesis in the hippocampus [87, 88]. Moreover, the nonpharmacological antidepressant treatment of electroconvulsive therapy (ECT) also enhances neurogenesis in the adult hippocampus [89, 90]. ECT is the most effective antidepressant treatment in depressed patients who are treatment resistant [91], and it can upregulate neurogenesis to levels nearly twice that of pharmacological antidepressants [89]. Similarly, recent human studies suggest that the broader acting, typically more efficacious, TCA and MAOI classes of antidepressant increase cell proliferation levels beyond that of SSRIs [23]; further indicating a role for hippocampal neurogenesis in successful antidepressant treatment.

Table 1.

Selected publications showing the effect of stress/depression or antidepressant treatment on neurogenesis and the functional importance of neurogenesis in antidepressant efficacy.

(a) Animal models of depression

Reference Species Sex Model Antidepressant Method of ablation Summary of findings
Snyder et al. 2011 [96] Mouse M Restraint X-ray; transgenic Neurogenesis-dependent regulation of HPA response to stress and behavioural measures (NSF, FST, and SC)
David et al. 2009 [64] Mouse M and F Chronic corticosterone administration Fluoxetine X-ray Neurogenesis-dependent (NSF) and -independent (OFT, FST) aspects of antidepressant efficacy
Bessa et al. 2009 [65] Rat M Chronic mild stress Imipramine; fluoxetine MAM Neurogenesis-dependent (NSF) and -independent (SC, FST) aspects of antidepressant efficacy. Significant alterations in neural plasticity associated with antidepressant efficacy
Surget et al. 2008 [92] Mouse M Chronic unpredictable stress Imipramine; fluoxetine Neurogenesis-dependent (NSF, CS, ST) and -independent (A) aspects of antidepressant efficacy
Holick et al. 2008 [93] Mouse M Fluoxetine X-ray Neurogenesis-independent effects of antidepressant efficacy
Airan et al. 2007 [94] Rat F Chronic mild stress Imipramine; fluoxetine X-ray Neurogenesis-dependent (NSF) and -independent (OFT) aspects of antidepressant efficacy
Alonso et al. 2004 [85] Mouse M Chronic mild stress Fluoxetine Decreased cell proliferation in the DG, while chronic fluoxetine blocked this effect
Santarelli et al. 2003 [21] Mouse M Imipramine; fluoxetine X-ray Neurogenesis-dependent (NSF) antidepressant efficacy
Czéh et al. 2002 [78] Rat M Social subordination Decreased cell proliferation and survival in the DG
Malberg et al. 2000 [9] Rat M Fluoxetine; reboxetine; tranylcypromine; ECS Chronic, but not acute, treatment with monoaminergic antidepressant and ECS increased cell proliferation in the DG

(b) Human studies of depression

Reference Subjects Sex Population assessed Antidepressant Effect on neurogenesis
Cobb et al. 2013 [74] Humans M and F Depressed patients postmortem No significant difference in number of granule cells between depressed subjects and controls; decreased hippocampal volume correlating with duration of disease
Boldrini et al. 2013 [75] Humans M and F Depressed patients postmortem SSRIs; TCAs Depression is associated with a decreased number of granule neurons, correlated with reduced DG volume. SSRI and TCA treatment increase granule neuron number and DG volume
Boldrini et al. 2012 [22] Humans M and F Depressed patients postmortem SSRIs; TCAs Both antidepressant classes increase cell proliferation over untreated depressed patients and controls; NPCs associated with angiogenesis
Boldrini et al. 2009 [23] Humans M and F Depressed patients postmortem SSRIs; TCAs Both antidepressant classes increase cell proliferation over untreated depressed patients and controls
Stockmeier et al. 2004 [76] Humans M and F Depressed patients postmortem Increased density of granule cells in the DG of depressed subjects compared to controls

NSF: novelty suppressed feeding; FST: forced swim test; SC: sucrose consumption; OFT: open field test; CS: coat state; ST: splash test; A: actimeter; MAM: methylazoxymethanol acetate (cytostatic agent).

While it is accepted that chronic antidepressant treatment upregulates hippocampal neurogenesis, some studies have suggested that increased neurogenesis is absolutely necessary for antidepressant efficacy. Specifically, if hippocampal neurogenesis is reduced via localized irradiation, antidepressants lose their behavioural efficacy in rodent models of depression [21]. However, use of the cytostatic agent methylazoxymethanol (MAM) to reduce hippocampal neurogenesis failed to disrupt the behavioural efficacy of chronic antidepressant treatment on sucrose preference or in the forced swim test; antidepressant treatment still increased hippocampal volume and NCAM expression, despite the disruption of hippocampal neurogenesis [65]. Nonetheless, neurogenesis does seem to be required for the attenuation of anxiety-like behaviour as measured in the novelty suppressed feeding (NSF) test, suggesting a role for neurogenesis in specific aspects of antidepressant efficacy. Indeed, further research has shown neurogenic-dependent and -independent effects of an antidepressant drug, where hippocampal neurogenesis is only required for the alleviation of some anxiety/depressive-like behaviour [64, 9294]. These findings point toward multifaceted and pleiotropic effects of antidepressants on neural circuitry. Interestingly anxiolytic drugs, such as benzodiazepines, also show efficacy in the NSF test with acute treatment, while antidepressants require chronic, neurogenesis-enhancing treatment [95]. It is then possible that the reduction in glucocorticoids from anxiolytic treatment mediates the reduction in anxiety-like behaviour in the NSF test; therefore antidepressant-induced neurogenesis may mediate a similar effect on glucocorticoid levels. Indeed this may be the case, as hippocampal neurogenesis buffers the stress response and normalizes glucocorticoid release after stress [96]. Synder and colleagues found that inhibition of hippocampal neurogenesis, either transgenically or via irradiation, attenuated the recovery of basal HPA tone following a stressor and the normal suppression of glucocorticoid release during the dexamethasone suppression test [96]. As such, there is likely a role for hippocampal neurogenesis in reestablishing normal HPA tone and regulating a normal HPA response, possibly through GR-mediated negative feedback. Thus the effectiveness of antidepressant treatment and the importance of ensuing neurogenesis within different behavioural measures of antidepressant efficacy may represent the underlying mechanisms through which antidepressants are exerting their effects. Separate facets of antidepressant-induced neural plasticity may therefore facilitate drug action such as neurogenesis-mediated normalization of the stress response in the NSF test versus modulation of monoaminergic tone through synaptic plasticity in the sucrose preference test and FST. Hence the contribution of broader neural plasticity, beyond neurogenesis, is also of interest and has been proposed as the underlying mechanism of antidepressant efficacy [65].

10. Potential Role for PSA-NCAM in Antidepressant Efficacy

The expression of PSA-NCAM within the adult nervous system is essential in multiple facets of neural plasticity, including neurogenesis, synaptic plasticity, and neurite outgrowth [10, 30, 31, 97, 98]. Importantly, PSA-NCAM functions across all aspects of hippocampal neurogenesis (proliferation, migration, differentiation, and survival), therefore changes in the polysialylation of newly generated neurons alter neurogenesis as a whole [99104] (see Table 2). For instance, chronic mild stress reduces the expression of both the core NCAM protein [65] and the addition of the PSA moiety [11, 105108] in the hippocampus; however these changes are dependent on the type of stressor [109] (see Table 3). Alterations in PSA-NCAM expression following stress are also seen in other regions associated with depression including the amygdala and prefrontal cortex [110113]. Similarly, PSA-NCAM expression is reduced in amygdala of patients with major depressive disorder [2, 114]; however no change is seen in the PFC [115]. Conversely, chronic antidepressant treatment modulates PSA-NCAM expression throughout the limbic system in animal models of depression. [11, 116119]. Moreover, antidepressant treatment reduces PSA-NCAM expression in the dorsal raphe nucleus [116], implicating PSA-NCAM in antidepressant-induced plasticity related to serotonergic neurotransmission. Taken together these findings suggest PSA-NCAM may play a fundamental role in mediating broad effects of antidepressant treatment across multiple forms of neural plasticity.

Table 2.

Selected publications delineating the role of PSA-NCAM in adult hippocampal neurogenesis.

Authors Species Role in neurogenesis Ablation method Findings
McCall et al. 2013 [97] Rat Neurite outgrowth; survival EndoN Cleavage of PSA-NCAM caused expanded dendritic arborization and increased cell death
Burgess et al. 2008 [10] Rat Migration; differentiation EndoN Cleavage of PSA-NCAM disrupts normal migration and differentiation of newly generated neurons in the DG
Seri et al. 2004 [99] ? Differentiation PSA-NCAM is highly expressed in the entire cell body and growing processes of D cells (precursors in the generation of new granule neurons in the dentate gyrus)
Ni Dhuill et al. 1999 [100] Human Proliferation; neurite outgrowth Hippocampal expression of PSA-NCAM throughout life in humans closely resembles that of the rat. Expression largely contained to granule cells of the dentate gyrus and their mossy fiber axons, with large reductions in expression with age
Seki and Rutishauser 1998 [98] Mouse Neurite outgrowth NCAM KO; EndoN Aberrant collateral sprouting of mossy fibers and ectopic synaptic bouton formation
Kuhn et al. 1996 [101] Rat Migration Age related decline in PSA-NCAM expression in the GCL, reduced migration of PSA-NCAM expressing cells into the GCL
Fox et al. 1995 [102] Rat Proliferation PSA-NCAM expression decreases with age, coinciding with decreased cell proliferation
Seki and Arai 1993 [103] Rat Proliferation; migration; differentiation Newly generated granule cells in the dentate gyrus express a highly polysialylated form of NCAM, involved in the migration of immature neurons from the subgranular zone into the GCL
Seki and Arai 1991 [104] Rat Proliferation Highly polysialylated form of NCAM is persistently expressed in the adult dentate gyrus

EndoN: endoneuraminidase N; GCL: granule cell layer.

Table 3.

Effects of stress and depression on the expression of PSA-NCAM.

(a) Animal models of stress and depression

Reference Species Sex Model Antidepressant Effect on PSA-NCAM
Gilabert-Juan et al. 2012 [110] Mouse M Chronic restraint stress in mPFC
Djordjevic et al. 2012 [111] Rat M Chronic social isolation ↑ in HPC; ↓ PFC
Djordjevic et al. 2012 [109] Rat M Chronic social isolation Fluoxetine ↑ in HPC, ↓ by Flx treatment
Djordjevic et al. 2012 [112] Rat M Chronic social isolation Fluoxetine ↑ in PFC; ↓ by Flx treatment (with stress)
Gilabert-Juan et al. 2011 [113] Mouse M Chronic restraint stress ↓ in CeM; in BLA; Me
Wainwright et al. 2011 [11] Rat M Unpredictable chronic mild stress ↓ in HPC
Homberg et al. 2011 [116] Rat M Fluoxetine ↓ in dRN; in mPFC; ↑ AMYG (adolescent), ↓ AMYG (adult)
Varea et al. 2007 [117] Rat M Fluoxetine ↑ in HPC (str. luc. only); ↓ in Me and BMA; in BLA
Sairanen et al. 2007 [118] Rat M Imipramine ↑ in HPC; ↑ plPFC
Varea et al. 2007 [119] Rat M Fluoxetine ↑ in mPFC (whole); ↑ ilPFC; plPFC
Cordero et al. 2005 [105] Rat M Chronic restraint stress ↓ in CeM; ↓ Me
Nacher et al. 2004 [66] Rat M Oral corticosterone administration ↓ in HPC
Nacher et al. 2004 [106] Rat M Chronic restraint stress; oral corticosterone administration ↓ in piriform cortex (oral CORT); ↑ in piriform cortex (restraint)
Pham et al. 2003 [107] Rat M Chronic restraint stress ↑ in HPC (3 weeks), in HPC (6 weeks)
Sandi et al. 2001 [108] Rat M Chronic restraint stress ↑ in HPC

(b) Human studies of depression

Reference Subjects Sex Population assessed Antidepressant Effect on PSA-NCAM
Maheu et al. 2013 [114] Human ? Depressed patients postmortem Specific classes not disclosed ↓ in BLA
Gilabert-Juan et al. 2012 [115] Human M and F Depressed patients postmortem Specific classes not disclosed in dlPFC
Varea et al. 2012 [2] Human M and F Depressed patients postmortem Specific classes not disclosed ↓ in BLA; ↓ in BMA

Me: medial amygdala; CeM: centromedial amygdala; BMA: basomedial amygdala; dRN: dorsal raphe nucleus; str. luc.: stratum lucidum; plPFC: prelimbic cortex; ilPFC: infralimbic prefrontal cortex; HPC: hippocampus; AMYG: amygdala; mPFC: medial prefrontal cortex.

Previous studies have shown PSA-NCAM is essential in the activity-dependent induction of hippocampal LTP and LTD [35], where the polysialylation of NCAM is positively correlated with neural activity of glutamatergic neurons [120, 121]. Moreover, inhibiting the polysialylation of NCAM reduces the rate of dendritic spine formation and decreases the stability of these spines [122]. Interestingly PSA-NCAM is also directly related to monoaminergic neurotransmission, as PSA-NCAM expression is directly modulated by the 5-HT1A receptor [123]. Moreover, serotonergic innervation plays a role in regulating the expression of PSA-NCAM in the hippocampus [124]. Given the interaction of serotonergic neurotransmission with PSA-NCAM and its putative role in regulating synaptic plasticity, it is possible that PSA-NCAM may mediate some of the effects of antidepressant treatment on monoaminergic tone.

The ability of PSA-NCAM to directly alter hippocampal neurogenesis is evidenced by the selective removal of the PSA moiety from NCAM with the bacteriophage enzyme EndoN. Application of EndoN disrupts normal migration of newly produced cells and alters differentiation of these new cells by shifting them toward a neuronal phenotype [10]. Selective cleavage of PSA also produces enhanced dendritic arborization, aberrant mossy fiber sprouting, produces ectopic synaptic bouton formation, and increases cell death within the hippocampus [97, 98].

Given the role of PSA-NCAM in mediating multiple aspects of neural plasticity it appears to function at the confluence of the prevailing theories of depression: monoaminergic, neurotrophic, and neurogenic, thus making it an interesting target for future study. Further research is necessary to elucidate the role of PSA-NCAM and similar proteins, in the etiology of depression and efficacy of antidepressant drugs.

11. Role of Neurotrophic Factors in Antidepressant Efficacy

Brain-derived neurotrophic factor (BDNF) has been implicated in the etiology and treatment of depression. Depressed patients show decreased levels of serum BDNF [125, 126], which is correlated with decreased hippocampal volume and increased ratings of depression [126]. Conversely, increased BDNF levels are associated with antidepressant treatment and alleviation of depression [127]. These findings are mirrored in rodent models of depression [128132] as chronic antidepressant treatment increases BDNF levels, coinciding with alleviation of depressive-like behaviours [130132], and intracranial infusion of BDNF produces antidepressant effects [128, 133].

Activation of the TrkB neurotrophin receptor largely mediates the plasticity-enhancing actions of BDNF [134136], where inhibition of TrkB signalling attenuates the behavioural efficacy of antidepressants [136]. Conversely BDNF, or more specifically proBDNF, via activation of the p75 neurotrophin receptor mediates plasticity-reducing actions such as apoptosis, neural atrophy, and synaptic pruning [137]. It has been postulated that the balance of TrkB and p75 signalling may underlie antidepressant effects of BDNF, suggesting a mechanism through which stress/depression may modulate the effects of BDNF. To this point, knocking out TrkB receptors fails to produce a depressive-like phenotype in neurogenesis-dependent or -independent behavioural measures of antidepressant efficacy [138, 139]; however sex differences exist as female TrkB knockouts do appear to develop a depressive-like behavioural phenotype [140].

Interestingly, PSA-NCAM interacts with BDNF, as removal of PSA from NCAM inhibits the induction of LTP, and the application of exogenous BDNF restores LTP at the affected synapse [141]. Further, disruption of the polysialylation of NCAM also disturbs the effects of BDNF on cortical neuron differentiation and survival, while the application of exogenous BDNF reverses these effects [142]. These findings suggest that PSA-NCAM may mediate the responsiveness of neurons to BDNF. It is known that PSA-NCAM interacts with, and may regulate, p75 expression in septal neurons [143] and newly generated neurons of the SVZ [144]. Indeed knockout of p75 significantly reduces the expression of PSA-NCAM in SVZ neuroblasts [145]. As previously mentioned the p75 receptor is involved in the regulation of adult hippocampal neurogenesis [146] and regulates neurogenesis stimulated by chronic antidepressant treatment [147]. Given the complex and varied role of BDNF in the etiology of depression and antidepressant treatment more research is needed to further elucidate a mechanism through which the modulation of BDNF exerts its influence.

12. Gonadal Hormones, Depression, and Modulation of Neural Plasticity

Women are twice as likely as men to develop depression [148]. Sex differences are also seen in antidepressant efficacy as men have a better response to TCAs, while women have a better response to SSRIs [149], although these findings remain controversial. Any sex difference observed suggests that gonadal hormone levels are involved, and indeed there is evidence that androgens may protect males from the development of depression. Interestingly, there is an increased incidence of depression in males coinciding with the age related decline in testosterone levels [150153]. Similarly, young hypogonadal males are more susceptible to developing depression [154], portending protective effects of testosterone against the development of depression. Testosterone has shown some antidepressant action as testosterone replacement therapies are efficacious in alleviating depressive symptoms in hypogonadal men [152, 155, 156]. Testosterone replacement also has efficacy as an adjunct treatment to clinical antidepressants in cases of treatment-resistant depression [155, 157]; however it should be noted that androgen therapies are not always seen to be effective for men suffering depression [158, 159].

Gonadal hormones in females are also likely a factor in the treatment and etiology of depression. Times of dramatic hormone fluctuation, such as during the postpartum and perimenopause, are associated with an increased incidence in depression [160, 161]. In addition hormonal replacement can show antidepressant effects during the postpartum and in peri- and postmenopausal women [162164]. Consistent with clinical studies, gonadal hormones are also effective as an adjunct therapy to chronic antidepressant treatment in animal models. For example, chronic imipramine increases hippocampal neurogenesis in intact but not in ovariectomized rats [165]. Another study found that an SSRI decreased immobility in the FST in ovariectomized female rats, but only with adjunct estradiol treatment [166]. Similarly, testosterone potentiates the effects of imipramine in increasing cell proliferation and facilitates the alleviation of depressive-like behavioural phenotypes in castrated socially isolated male rats [167]. Consequently androgens and estrogens may have antidepressant properties which could impede the development of, or ameliorate, extant depressive disorders.

Interestingly gonadal hormones modulate adult neurogenesis, BDNF levels, and PSA-NCAM expression in the hippocampus. Testosterone and its metabolite dihydrotestosterone (DHT) both serve to enhance hippocampal neurogenesis through improved cell survival via an androgen-dependent mechanism within the dentate gyrus [168]. Similarly, estrogens are able to increase adult neurogenesis via proliferation or survival depending on duration of treatment [169]. Estrogens regulate the polysialylation of NCAM across the estrous cycle [170], while the removal of testicular hormones decreases PSA-NCAM expression in the dentate gyrus [11]. Significant interplay exists between gonadal hormones and BDNF, as testosterone and DHT interact with BDNF to modulate synaptic plasticity, dendritic morphology, and neurogenesis in the central nervous system [171174]. Estrogens and BDNF also share widespread interactions, as estradiol regulates hippocampal BDNF [175, 176] levels possibly through an estrogen-sensitive response element on the BDNF gene [177]. Conversely, BDNF mediates estradiol-induced alterations in hippocampal dendritic spine density [178]. Thus gonadal hormones may play a role in facilitating antidepressant efficacy through the modulation of neural plasticity.

13. Effects of Experimental Manipulation on Neural Plasticity

Many of the studies examining a reduction in neurogenesis have used viral vectors, irradiation, or the cytostatic agent, methylazoxymethanol. It is important to note that the experimental manipulation of neurogenesis also likely produces downstream effects on neural plasticity in a much broader sense, including the expression of cell adhesion molecules (including PSA-NCAM), synaptic proteins, and BDNF. As such, it is difficult to know for sure whether the attenuation of antidepressant efficacy via reductions in neurogenesis is due to changes in neurogenesis levels or other aspects of neural plasticity. For instance, radiation levels as low as 2.5 Gy significantly reduce the density of BDNF-expressing neurons [179] and the expression of PSA-NCAM in the hippocampus [180]. This is important as a 10 Gy dose of radiation is typically used to inhibit neurogenesis in studies assessing attenuated neurogenesis [21, 96, 181], suggesting BDNF and PSA-NCAM expression will also be affected. This suggests that the effects of radiation affect proteins associated with neural remodelling and synaptic plasticity as well as neurogenesis [180]. It is important to address these caveats in future research to further elucidate the role of neurogenesis and neural plasticity in depression and its treatment.

14. Conclusion

Depression is a complex neuropsychiatric disease with a poorly defined etiology. While hosts of antidepressant drugs do exist, they are often inefficacious. Elucidating the neural underpinnings of depression and fully understanding the pleiotropic effects of current antidepressant compounds, beyond their role in modulating monoaminergic neurotransmission, are necessary for the development of more effective drugs. The potential role of neurogenesis, both its decline with the occurrence of depression and its enhancement by chronic treatment with antidepressant drugs and therapies, has provided a promising avenue for research. Though significant findings have been made relating neurogenesis to the effective treatment of depression, large gaps in our understanding still exist. To this end, the role of synaptic proteins and cell adhesion molecules, including PSA-NCAM, in the etiology and treatment of depression should also be investigated. As with neurogenesis, PSA-NCAM is reduced in depressed patients and in models of depression, while chronic antidepressant treatment increases expression of PSA-NCAM. Importantly however, PSA-NCAM mediates multiple facets of neural plasticity, including neurogenesis and synaptic plasticity, in addition to mediating effects of neurotrophic factors, such as BDNF. PSA-NCAM therefore functions at the confluence of many forms of neural plasticity, and its mechanisms bridge several theories of depression: monoamine, neurogenic, and neurotrophic. This review has focused on the potential roles of neurogenesis and PSA-NCAM in depression; however many other proteins are associated with neural plasticity and depression [29, 182, 183]. Given the limitations in the understanding of the genesis of depression and current antidepressant treatments, continued research into the exact contribution of adult neurogenesis and the potential roles of proteins associated with neural plasticity and the continued perusal of a broader, neural plasticity hypothesis of depression are certainly warranted.

Acknowledgment

Liisa A. M. Galea was funded for this research by a grant from the Coast Capital Depression Fund.

References

  • 1.Wilbrecht L, Holtmaat A, Wright N, Fox K, Svoboda K. Structural plasticity underlies experience-dependent functional plasticity of cortical circuits. Journal of Neuroscience. 2010;30(14):4927–4932. doi: 10.1523/JNEUROSCI.6403-09.2010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Varea E, Guirado R, Gilabert-Juan J, et al. Expression of PSA-NCAM and synaptic proteins in the amygdala of psychiatric disorder patients. Journal of Psychiatric Research. 2012;46(2):189–197. doi: 10.1016/j.jpsychires.2011.10.011. [DOI] [PubMed] [Google Scholar]
  • 3.DeKosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer’s disease: correlation with cognitive severity. Annals of Neurology. 1990;27(5):457–464. doi: 10.1002/ana.410270502. [DOI] [PubMed] [Google Scholar]
  • 4.Calabresi P, Mercuri NB, Di Filippo M. Synaptic plasticity, dopamine and Parkinson’s disease: one step ahead. Brain. 2009;132(2):285–287. doi: 10.1093/brain/awn340. [DOI] [PubMed] [Google Scholar]
  • 5.Lewis DA, González-Burgos G. Neuroplasticity of neocortical circuits in schizophrenia. Neuropsychopharmacology. 2008;33(1):141–165. doi: 10.1038/sj.npp.1301563. [DOI] [PubMed] [Google Scholar]
  • 6.Altman J. Are new neurons formed in the brains of adult mammals? Science. 1962;135(3509):1127–1128. doi: 10.1126/science.135.3509.1127. [DOI] [PubMed] [Google Scholar]
  • 7.Eriksson PS, Perfilieva E, Björk-Eriksson T, et al. Neurogenesis in the adult human hippocampus. Nature Medicine. 1998;4(11):1313–1317. doi: 10.1038/3305. [DOI] [PubMed] [Google Scholar]
  • 8.Kaplan MS, Hinds JW. Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs. Science. 1977;197(4308):1092–1094. doi: 10.1126/science.887941. [DOI] [PubMed] [Google Scholar]
  • 9.Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. Journal of Neuroscience. 2000;20(24):9104–9110. doi: 10.1523/JNEUROSCI.20-24-09104.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Burgess A, Wainwright SR, Shihabuddin LS, Rutishauser U, Seki T, Aubert I. Polysialic acid regulates the clustering, migration, and neuronal differentiation of progenitor cells in the adult hippocampus. Developmental Neurobiology. 2008;68(14):1580–1590. doi: 10.1002/dneu.20681. [DOI] [PubMed] [Google Scholar]
  • 11.Wainwright SR, Lieblich SE, Galea LA. Hypogonadism predisposes males to the development of behavioural and neuroplastic depressive phenotypes. Psychoneuroendocrinology. 2011;36(9):1327–1341. doi: 10.1016/j.psyneuen.2011.03.004. [DOI] [PubMed] [Google Scholar]
  • 12.Kempermann G, Kuhn HG, Gage FH. Experience-induced neurogenesis in the senescent dentate gyrus. Journal of Neuroscience. 1998;18(9):3206–3212. doi: 10.1523/JNEUROSCI.18-09-03206.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Barker JM, Galea LAM. Repeated estradiol administration alters different aspects of neurogenesis and cell death in the hippocampus of female, but not male, rats. Neuroscience. 2008;152(4):888–902. doi: 10.1016/j.neuroscience.2007.10.071. [DOI] [PubMed] [Google Scholar]
  • 14.van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nature Neuroscience. 1999;2(3):266–270. doi: 10.1038/6368. [DOI] [PubMed] [Google Scholar]
  • 15.Kempermann G. Why new neurons? Possible functions for adult hippocampal neurogenesis. Journal of Neuroscience. 2002;22(3):635–638. doi: 10.1523/JNEUROSCI.22-03-00635.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Duman RS, Malberg J, Nakagawa S. Regulation of adult neurogenesis by psychotropic drugs and stress. Journal of Pharmacology and Experimental Therapeutics. 2001;299(2):401–407. [PubMed] [Google Scholar]
  • 17.Epp JR, Spritzer MD, Galea LAM. Hippocampus-dependent learning promotes survival of new neurons in the dentate gyrus at a specific time during cell maturation. Neuroscience. 2007;149(2):273–285. doi: 10.1016/j.neuroscience.2007.07.046. [DOI] [PubMed] [Google Scholar]
  • 18.Snyder JS, Hong NS, McDonald RJ, Wojtowicz JM. A role for adult neurogenesis in spatial long-term memory. Neuroscience. 2005;130(4):843–852. doi: 10.1016/j.neuroscience.2004.10.009. [DOI] [PubMed] [Google Scholar]
  • 19.Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ. Learning enhances adult neurogenesis in the hippocampal formation. Nature Neuroscience. 1999;2(3):260–265. doi: 10.1038/6365. [DOI] [PubMed] [Google Scholar]
  • 20.Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E. Neurogenesis in the adult is involved in the formation of trace memories. Nature. 2001;410(6826):372–376. doi: 10.1038/35066584. [DOI] [PubMed] [Google Scholar]
  • 21.Santarelli L, Saxe M, Gross C, et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science. 2003;301(5634):805–809. doi: 10.1126/science.1083328. [DOI] [PubMed] [Google Scholar]
  • 22.Boldrini M, Hen R, Underwood MD, et al. Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression. Biological Psychiatry. 2012;72(7):562–571. doi: 10.1016/j.biopsych.2012.04.024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Boldrini M, Underwood MD, Hen R, et al. Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology. 2009;34(11):2376–2389. doi: 10.1038/npp.2009.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Fanselow MS, Dong HW. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron. 2010;65(1):7–19. doi: 10.1016/j.neuron.2009.11.031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25.Bannerman DM, Rawlins JN, McHugh SB, et al. Regional dissociations within the hippocampus—memory and anxiety. Neuroscience & Biobehavioral Reviews. 2004;28(3):273–283. doi: 10.1016/j.neubiorev.2004.03.004. [DOI] [PubMed] [Google Scholar]
  • 26.Gärtner A, Frantz D. Hippocampus: Anatomy, Functions and Neurobiology. Neuroanatomy Research at the Leading Edge Series. Vol. 11. New York, NY, USA: Nova Science; 2010. [Google Scholar]
  • 27.Koehl M, Abrous DN. A new chapter in the field of memory: adult hippocampal neurogenesis. European Journal of Neuroscience. 2011;33(6):1101–1114. doi: 10.1111/j.1460-9568.2011.07609.x. [DOI] [PubMed] [Google Scholar]
  • 28.Dalva MB, McClelland AC, Kayser MS. Cell adhesion molecules: signalling functions at the synapse. Nature Reviews Neuroscience. 2007;8(3):206–220. doi: 10.1038/nrn2075. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29.Sandi C. Stress, cognitive impairment and cell adhesion molecules. Nature Reviews Neuroscience. 2004;5(12):917–930. doi: 10.1038/nrn1555. [DOI] [PubMed] [Google Scholar]
  • 30.Bonfanti L. PSA-NCAM in mammalian structural plasticity and neurogenesis. Progress in Neurobiology. 2006;80(3):129–164. doi: 10.1016/j.pneurobio.2006.08.003. [DOI] [PubMed] [Google Scholar]
  • 31.Bonfanti L, Theodosis DT. Polysialic acid and activity-dependent synapse remodeling. Cell Adhesion and Migration. 2009;3(1):43–50. doi: 10.4161/cam.3.1.7258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 32.Senkov O, Tikhobrazova O, Dityatev A. PSA-NCAM: synaptic functions mediated by its interactions with proteoglycans and glutamate receptors. The International Journal of Biochemistry & Cell Biology. 2012;44(4):591–595. doi: 10.1016/j.biocel.2012.01.008. [DOI] [PubMed] [Google Scholar]
  • 33.Finne J, Finne U, Deagostini-Bazin H, Goridis C. Occurrence of α2-8 linked polysialosyl units in a neural cell adhesion molecule. Biochemical and Biophysical Research Communications. 1983;112(2):482–487. doi: 10.1016/0006-291x(83)91490-0. [DOI] [PubMed] [Google Scholar]
  • 34.Gascon E, Vutskits L, Kiss JZ. Polysialic acid-neural cell adhesion molecule in brain plasticity: from synapses to integration of new neurons. Brain Research Reviews. 2007;56(1):101–118. doi: 10.1016/j.brainresrev.2007.05.014. [DOI] [PubMed] [Google Scholar]
  • 35.Muller D, Wang C, Skibo G, et al. PSA-NCAM is required for activity-induced synaptic plasticity. Neuron. 1996;17(3):413–422. doi: 10.1016/s0896-6273(00)80174-9. [DOI] [PubMed] [Google Scholar]
  • 36.Rutishauser U, Watanabe M, Silver J. Specific alteration of NCAM-mediated cell adhesion by an endoneuraminidase. Journal of Cell Biology. 1985;101(5):1842–1849. doi: 10.1083/jcb.101.5.1842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 37.Ustun TB, Ayuso-Mateos JL, Chatterji S, Mathers C, Murray CJL. Global burden of depressive disorders in the year 2000. The British Journal of Psychiatry. 2004;184:386–392. doi: 10.1192/bjp.184.5.386. [DOI] [PubMed] [Google Scholar]
  • 38.Greenberg PE, Birnbaum HG. The economic burden of depression in the US: societal and patient perspectives. Expert Opinion on Pharmacotherapy. 2005;6(3):369–376. doi: 10.1517/14656566.6.3.369. [DOI] [PubMed] [Google Scholar]
  • 39.American Psychiatric Association. Diagnostic Criteria From DSM-IV-TR. Vol. 12. Washington, DC, USA: American Psychiatric Association; 2000. [Google Scholar]
  • 40.Byrne SE, Rothschild AJ. Loss of antidepressant efficacy during maintenance therapy: possible mechanisms and treatments. Journal of Clinical Psychiatry. 1998;59(6):279–288. doi: 10.4088/jcp.v59n0602. [DOI] [PubMed] [Google Scholar]
  • 41.Trivedi MH, Rush AJ, Wisniewski SR, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR∗D: implications for clinical practice. American Journal of Psychiatry. 2006;163(1):28–40. doi: 10.1176/appi.ajp.163.1.28. [DOI] [PubMed] [Google Scholar]
  • 42.Piñeyro G, Blier P. Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacological Reviews. 1999;51(3):533–591. [PubMed] [Google Scholar]
  • 43.Crane GE. Iproniazid (marsilid) phosphate, a therapeutic agent for mental disorders and debilitating diseases. Psychiatric Research Reports. 1957;8:142–152. [PubMed] [Google Scholar]
  • 44.Selikoff IJ, Robitzek EH, Ornstein GG. Treatment of pulmonary tuberculosis with hydrazide derivatives of isonicotinic acid. Journal of the American Medical Association. 1952;150(10):973–980. doi: 10.1001/jama.1952.03680100015006. [DOI] [PubMed] [Google Scholar]
  • 45.KUHN R. The treatment of depressive states with G 22355 (imipramine hydrochloride) The American Journal of Psychiatry. 1958;115(5):459–464. doi: 10.1176/ajp.115.5.459. [DOI] [PubMed] [Google Scholar]
  • 46.Fangmann P, Assion HJ, Juckel G, González CÁ, López-Muñoz F. Half a century of antidepressant drugs: on the clinical introduction of monoamine oxidase inhibitors, tricyclics, and tetracyclics. Part II: tricyclics and tetracyclics. Journal of Clinical Psychopharmacology. 2008;28(1):1–4. doi: 10.1097/jcp.0b013e3181627b60. [DOI] [PubMed] [Google Scholar]
  • 47.López-Muñoz F, Álamo C, Juckel G, Assion HJ. Half a century of antidepressant drugs: on the clinical introduction of monoamine oxidase inhibitors, tricyclics, and tetracyclics. Part I: monoamine oxidase inhibitors. Journal of Clinical Psychopharmacology. 2007;27(6):555–559. doi: 10.1097/jcp.0b013e3181bb617. [DOI] [PubMed] [Google Scholar]
  • 48.Hirschfeld RMA. History and evolution of the monoamine hypothesis of depression. Journal of Clinical Psychiatry. 2000;61(supplement 6):4–6. [PubMed] [Google Scholar]
  • 49.Thase ME, Trivedi MH, Rush AJ. MAOIs in the contemporary treatment of depression. Neuropsychopharmacology. 1995;12(3):185–219. doi: 10.1016/0893-133X(94)00058-8. [DOI] [PubMed] [Google Scholar]
  • 50.Thase ME. Effectiveness of antidepressants: comparative remission rates. Journal of Clinical Psychiatry. 2003;64(supplement 2):3–7. [PubMed] [Google Scholar]
  • 51.Quitkin FM, Rabkin JD, Markowitz JM. Use of pattern analysis to identify true drug response: a replication. Archives of General Psychiatry. 1987;44(3):259–264. doi: 10.1001/archpsyc.1987.01800150071009. [DOI] [PubMed] [Google Scholar]
  • 52.Anderson IM, Nutt DJ, Deakin JFW. Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines. Journal of Psychopharmacology. 2000;14(1):3–20. doi: 10.1177/026988110001400101. [DOI] [PubMed] [Google Scholar]
  • 53.Blier P. The pharmacology of putative early-onset antidepressant strategies. European Neuropsychopharmacology. 2003;13(2):57–66. doi: 10.1016/s0924-977x(02)00173-6. [DOI] [PubMed] [Google Scholar]
  • 54.Quitkin FM, Rabkin JG, Ross D. Identification of true drug response to antidepressants. Use of pattern analysis. Archives of General Psychiatry. 1984;41(8):782–786. doi: 10.1001/archpsyc.1984.01790190056007. [DOI] [PubMed] [Google Scholar]
  • 55.Blier P, De Montigny C, Chaput Y. Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression. Journal of Clinical Psychopharmacology. 1987;7(supplement 6):24S–35S. [PubMed] [Google Scholar]
  • 56.Stahl S. Is serotonin receptor down-regulation linked to the mechanism of action of antidepressant drugs? Psychopharmacology Bulletin. 1994;30(1):39–43. [PubMed] [Google Scholar]
  • 57.Lieben CKJ, Steinbusch HWM, Blokland A. 5,7-DHT lesion of the dorsal raphe nuclei impairs object recognition but not affective behavior and corticosterone response to stressor in the rat. Behavioural Brain Research. 2006;168(2):197–207. doi: 10.1016/j.bbr.2005.11.003. [DOI] [PubMed] [Google Scholar]
  • 58.Jacobs BL, Van Praag H, Gage FH. Adult brain neurogenesis and psychiatry: a novel theory of depression. Molecular Psychiatry. 2000;5(3):262–269. doi: 10.1038/sj.mp.4000712. [DOI] [PubMed] [Google Scholar]
  • 59.Schüle C. Neuroendocrinological mechanisms of actions of antidepressant drugs. Journal of Neuroendocrinology. 2007;19(3):213–226. doi: 10.1111/j.1365-2826.2006.01516.x. [DOI] [PubMed] [Google Scholar]
  • 60.Parker KJ, Schatzberg AF, Lyons DM. Neuroendocrine aspects of hypercortisolism in major depression. Hormones and Behavior. 2003;43(1):60–66. doi: 10.1016/s0018-506x(02)00016-8. [DOI] [PubMed] [Google Scholar]
  • 61.Ising M, Horstmann S, Kloiber S, et al. Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression-a potential biomarker? Biological Psychiatry. 2007;62(1):47–54. doi: 10.1016/j.biopsych.2006.07.039. [DOI] [PubMed] [Google Scholar]
  • 62.Keck ME. Corticotropin-releasing factor, vasopressin and receptor systems in depression and anxiety. Amino Acids. 2006;31(3):241–250. doi: 10.1007/s00726-006-0333-y. [DOI] [PubMed] [Google Scholar]
  • 63.Vollmayr B, Mahlstedt MM, Henn FA. Neurogenesis and depression: what animal models tell us about the link. European Archives of Psychiatry and Clinical Neuroscience. 2007;257(5):300–303. doi: 10.1007/s00406-007-0734-2. [DOI] [PubMed] [Google Scholar]
  • 64.David DJ, Samuels BA, Rainer Q, et al. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron. 2009;62(4):479–493. doi: 10.1016/j.neuron.2009.04.017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 65.Bessa JM, Ferreira D, Melo I, et al. The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Molecular Psychiatry. 2009;14(8):764–773. doi: 10.1038/mp.2008.119. [DOI] [PubMed] [Google Scholar]
  • 66.Nacher J, Gomez-Climent MA, McEwen B. Chronic non-invasive glucocorticoid administration decreases polysialylated neural cell adhesion molecule expression in the adult rat dentate gyrus. Neuroscience Letters. 2004;370(1):40–44. doi: 10.1016/j.neulet.2004.07.062. [DOI] [PubMed] [Google Scholar]
  • 67.Willner P. Chronic mild stress (CMS) revisited: consistency and behavioural- neurobiological concordance in the effects of CMS. Neuropsychobiology. 2005;52(2):90–110. doi: 10.1159/000087097. [DOI] [PubMed] [Google Scholar]
  • 68.Sapolsky RM, Meaney MJ, McEwen BS. The development of the glucocorticoid receptor system in the rat limbic brain. III. Negative-feedback regulation. Brain Research. 1985;350(1-2):169–173. doi: 10.1016/0165-3806(85)90261-5. [DOI] [PubMed] [Google Scholar]
  • 69.Sapolsky RM. Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels. Journal of Neuroscience. 1986;6(8):2240–2244. doi: 10.1523/JNEUROSCI.06-08-02240.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 70.Sapolsky RM, Packan DR, Vale WW. Glucocorticoid toxicity in the hippocampus: in vitro demonstration. Brain Research. 1988;453(1-2):367–371. doi: 10.1016/0006-8993(88)90180-1. [DOI] [PubMed] [Google Scholar]
  • 71.Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW. Hippocampal atrophy in recurrent major depression. Proceedings of the National Academy of Sciences of the United States of America. 1996;93(9):3908–3913. doi: 10.1073/pnas.93.9.3908. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 72.Sheline YI, Gado MH, Kraemer HC. Untreated depression and hippocampal volume loss. American Journal of Psychiatry. 2003;160(8):1516–1518. doi: 10.1176/appi.ajp.160.8.1516. [DOI] [PubMed] [Google Scholar]
  • 73.McKinnon MC, Yucel K, Nazarov A, MacQueen GM. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. Journal of Psychiatry and Neuroscience. 2009;34(1):41–54. [PMC free article] [PubMed] [Google Scholar]
  • 74.Cobb JA, Simpson J, Mahajan GJ, et al. Hippocampal volume and total cell numbers in major depressive disorder. Journal of Psychiatric Research. 2013;47(3):299–306. doi: 10.1016/j.jpsychires.2012.10.020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 75.Boldrini M, Santiago AN, Hen R, et al. Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression. Neuropsychopharmacology. 2013 doi: 10.1038/npp.2013.5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 76.Stockmeier CA, Mahajan GJ, Konick LC, et al. Cellular changes in the postmortem hippocampus in major depression. Biological Psychiatry. 2004;56(9):640–650. doi: 10.1016/j.biopsych.2004.08.022. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 77.Hercher C, Turecki G, Mechawar N. Through the looking glass: examining neuroanatomical evidence for cellular alterations in major depression. Journal of Psychiatric Research. 2009;43(11):947–961. doi: 10.1016/j.jpsychires.2009.01.006. [DOI] [PubMed] [Google Scholar]
  • 78.Czéh B, Welt T, Fischer AK, et al. Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis. Biological Psychiatry. 2002;52(11):1057–1065. doi: 10.1016/s0006-3223(02)01457-9. [DOI] [PubMed] [Google Scholar]
  • 79.Galea LAM, McEwen BS, Tanapat P, Deak T, Spencer RL, Dhabhar FS. Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress. Neuroscience. 1997;81(3):689–697. doi: 10.1016/s0306-4522(97)00233-9. [DOI] [PubMed] [Google Scholar]
  • 80.Watanabe Y, Gould E, McEwen BS. Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Research. 1992;588(2):341–345. doi: 10.1016/0006-8993(92)91597-8. [DOI] [PubMed] [Google Scholar]
  • 81.Shors TJ, Chua C, Falduto J. Sex differences and opposite effects of stress on dendritic spine density in the male versus female hippocampus. Journal of Neuroscience. 2001;21(16):6292–6297. doi: 10.1523/JNEUROSCI.21-16-06292.2001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 82.Müller HK, Wegener G, Popoli M, Elfving B. Differential expression of synaptic proteins after chronic restraint stress in rat prefrontal cortex and hippocampus. Brain Research. 2011;1385:26–37. doi: 10.1016/j.brainres.2011.02.048. [DOI] [PubMed] [Google Scholar]
  • 83.Czéh B, Michaelis T, Watanabe T, et al. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proceedings of the National Academy of Sciences of the United States of America. 2001;98(22):12796–12801. doi: 10.1073/pnas.211427898. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 84.Gould E, McEwen BS, Tanapat P, Galea LAM, Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. Journal of Neuroscience. 1997;17(7):2492–2498. doi: 10.1523/JNEUROSCI.17-07-02492.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 85.Alonso R, Griebel G, Pavone G, Stemmelin J, Le Fur G, Soubrié P. Blockade of CRF1 or V1b receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression. Molecular Psychiatry. 2004;9(3):278–286. doi: 10.1038/sj.mp.4001464. [DOI] [PubMed] [Google Scholar]
  • 86.Malberg JE, Duman RS. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003;28(9):1562–1571. doi: 10.1038/sj.npp.1300234. [DOI] [PubMed] [Google Scholar]
  • 87.Banasr M, Soumier A, Hery M, Mocaër E, Daszuta A. Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis. Biological Psychiatry. 2006;59(11):1087–1096. doi: 10.1016/j.biopsych.2005.11.025. [DOI] [PubMed] [Google Scholar]
  • 88.Dagyte G, Trentani A, Postema F, et al. The novel antidepressant agomelatine normalizes hippocampal neuronal activity and promotes neurogenesis in chronically stressed rats. CNS Neuroscience and Therapeutics. 2010;16(4):195–207. doi: 10.1111/j.1755-5949.2009.00125.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 89.Madsen TM, Treschow A, Bengzon J, Bolwig TG, Lindvall O, Tingström A. Increased neurogenesis in a model of electroconvulsive therapy. Biological Psychiatry. 2000;47(12):1043–1049. doi: 10.1016/s0006-3223(00)00228-6. [DOI] [PubMed] [Google Scholar]
  • 90.Hellsten J, Wennström M, Mohapel P, Ekdahl CT, Bengzon J, Tingström A. Electroconvulsive seizures increase hippocampal neurogenesis after chronic corticosterone treatment. European Journal of Neuroscience. 2002;16(2):283–290. doi: 10.1046/j.1460-9568.2002.02093.x. [DOI] [PubMed] [Google Scholar]
  • 91.Pagnin D, De Queiroz V, Pini S, Cassano GB. Efficacy of ECT in depression: a meta-analytic review. Journal of ECT. 2004;20(1):13–20. doi: 10.1097/00124509-200403000-00004. [DOI] [PubMed] [Google Scholar]
  • 92.Surget A, Saxe M, Leman S, et al. Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biological Psychiatry. 2008;64(4):293–301. doi: 10.1016/j.biopsych.2008.02.022. [DOI] [PubMed] [Google Scholar]
  • 93.Holick KA, Lee DC, Hen R, Dulawa SC. Behavioral effects of chronic fluoxetine in BALB/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor. Neuropsychopharmacology. 2008;33(2):406–417. doi: 10.1038/sj.npp.1301399. [DOI] [PubMed] [Google Scholar]
  • 94.Airan RD, Meltzer LA, Roy M, Gong Y, Chen H, Deisseroth K. High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science. 2007;317(5839):819–823. doi: 10.1126/science.1144400. [DOI] [PubMed] [Google Scholar]
  • 95.Bodnoff SR, Suranyi-Cadotte B, Quirion R, Meaney MJ. A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxiety. Psychopharmacology. 1989;97(2):277–279. doi: 10.1007/BF00442264. [DOI] [PubMed] [Google Scholar]
  • 96.Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA. Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature. 2011;476(7361):458–461. doi: 10.1038/nature10287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 97.McCall T, Weil ZM, Nacher J, et al. Depletion of polysialic acid from neural cell adhesion molecule (PSA-NCAM) increases CA3 dendritic arborization and increases vulnerability to excitotoxicity. Experimental Neurology. 2013;241:5–12. doi: 10.1016/j.expneurol.2012.11.028. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 98.Seki T, Rutishauser U. Removal of polysialic acid-neural cell adhesion molecule induces aberrant mossy fiber innervation and ectopic synaptogenesis in the hippocampus. Journal of Neuroscience. 1998;18(10):3757–3766. doi: 10.1523/JNEUROSCI.18-10-03757.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 99.Seri B, García-Verdugo JM, Collado-Morente L, McEwen BS, Alvarez-Buylla A. Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus. Journal of Comparative Neurology. 2004;478(4):359–378. doi: 10.1002/cne.20288. [DOI] [PubMed] [Google Scholar]
  • 100.Ni Dhuill CM, Fox GB, Pittock SJ, O'Connell AW, Murphy KJ, Regan CM. Polysialylated neural cell adhesion molecule expression in the dentate gyrus of the human hippocampal formation from infancy to old age. Journal of Neuroscience Research. 1999;55(1):99–106. doi: 10.1002/(SICI)1097-4547(19990101)55:1<99::AID-JNR11>3.0.CO;2-S. [DOI] [PubMed] [Google Scholar]
  • 101.Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. Journal of Neuroscience. 1996;16(6):2027–2033. doi: 10.1523/JNEUROSCI.16-06-02027.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 102.Fox GB, Kennedy N, Regan CM. Polysialylated neural cell adhesion molecule expression by neurons and astroglial processes in the rat dentate gyrus declines dramatically with increasing age. International Journal of Developmental Neuroscience. 1995;13(7):663–672. doi: 10.1016/0736-5748(95)00067-4. [DOI] [PubMed] [Google Scholar]
  • 103.Seki T, Arai Y. Highly polysialylated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat. Journal of Neuroscience. 1993;13(6):2351–2358. doi: 10.1523/JNEUROSCI.13-06-02351.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 104.Seki T, Arai Y. The persistent expression of a highly polysialylated NCAM in the dentate gyrus of the adult rat. Neuroscience Research. 1991;12(4):503–513. doi: 10.1016/s0168-0102(09)80003-5. [DOI] [PubMed] [Google Scholar]
  • 105.Cordero MI, Rodríguez JJ, Davies HA, Peddie CJ, Sandi C, Stewart MG. Chronic restraint stress down-regulates amygdaloid expression of polysialylated neural cell adhesion molecule. Neuroscience. 2005;133(4):903–910. doi: 10.1016/j.neuroscience.2005.03.046. [DOI] [PubMed] [Google Scholar]
  • 106.Nacher J, Pham K, Gil-Fernandez V, Mcewen BS. Chronic restraint stress and chronic corticosterone treatment modulate differentially the expression of molecules related to structural plasticity in the adult rat piriform cortex. Neuroscience. 2004;126(2):503–509. doi: 10.1016/j.neuroscience.2004.03.038. [DOI] [PubMed] [Google Scholar]
  • 107.Pham K, Nacher J, Hof PR, McEwen BS. Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus. European Journal of Neuroscience. 2003;17(4):879–886. doi: 10.1046/j.1460-9568.2003.02513.x. [DOI] [PubMed] [Google Scholar]
  • 108.Sandi C, Merino JJ, Cordero MI, Touyarot K, Venero C. Effects of chronic stress on contextual fear conditioning and the hippocampal expression of the neural cell adhesion molecule, its polysialylation, and L1. Neuroscience. 2001;102(2):329–339. doi: 10.1016/s0306-4522(00)00484-x. [DOI] [PubMed] [Google Scholar]
  • 109.Djordjevic A, Djordjevic J, Elakovic I, Adzic M, Matic G, Radojcic MB. Fluoxetine affects hippocampal plasticity, apoptosis and depressive-like behavior of chronically isolated rats. Prog Neuropsychopharmacol Biol Psychiatry. 2012;36(1):92–100. doi: 10.1016/j.pnpbp.2011.10.006. [DOI] [PubMed] [Google Scholar]
  • 110.Gilabert-Juan J, Castillo-Gomez E, Guirado R, Molto MD, Nacher J. Chronic stress alters inhibitory networks in the medial prefrontal cortex of adult mice. Brain Structure and Function. 2012 doi: 10.1007/s00429-012-0479-1. [DOI] [PubMed] [Google Scholar]
  • 111.Djordjevic J, Djordjevic A, Adzic M, Radojcic MB. Effects of chronic social isolation on Wistar rat behavior and brain plasticity markers. Neuropsychobiology. 2012;66(2):112–119. doi: 10.1159/000338605. [DOI] [PubMed] [Google Scholar]
  • 112.Djordjevic A, Djordjevic J, Elakovic I, Adzic M, Matic G, Radojcic MB. Effects of fluoxetine on plasticity and apoptosis evoked by chronic stress in rat prefrontal cortex. European Journal of Pharmacology. 2012;693(1–3):37–44. doi: 10.1016/j.ejphar.2012.07.042. [DOI] [PubMed] [Google Scholar]
  • 113.Gilabert-Juan J, Castillo-Gomeza E, Pérez-Randoa M, Dolores Moltَb M, Nachera J. Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice. Experimental Neurology. 2011;232(1):33–40. doi: 10.1016/j.expneurol.2011.07.009. [DOI] [PubMed] [Google Scholar]
  • 114.Maheu ME, Davoli MA, Turecki G, Mechawar N. Amygdalar expression of proteins associated with neuroplasticity in major depression and suicide. Journal of Psychiatric Research. 2013;47(3):384–390. doi: 10.1016/j.jpsychires.2012.11.013. [DOI] [PubMed] [Google Scholar]
  • 115.Gilabert-Juan J, Varea E, Guirado R, Blasco-Ibanez JM, Crespo C, Nacher J. Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients. Neuroscience Letters. 2012;530(1):97–102. doi: 10.1016/j.neulet.2012.09.032. [DOI] [PubMed] [Google Scholar]
  • 116.Homberg JR, Olivier JDA, Blom T, et al. Fluoxetine exerts age-dependent effects on behavior and amygdala neuroplasticity in the rat. PLoS ONE. 2011;6(1) doi: 10.1371/journal.pone.0016646.e16646 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 117.Varea E, Castillo-Gómez E, Gómez-Climent MA, et al. Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon. European Neuropsychopharmacology. 2007;17(8):546–557. doi: 10.1016/j.euroneuro.2007.01.001. [DOI] [PubMed] [Google Scholar]
  • 118.Sairanen M, O’Leary OF, Knuuttila JE, Castrén E. Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat. Neuroscience. 2007;144(1):368–374. doi: 10.1016/j.neuroscience.2006.08.069. [DOI] [PubMed] [Google Scholar]
  • 119.Varea E, Blasco-Ibáñez JM, Gómez-Climent MÁ, et al. Chronic fluoxetine treatment increases the expression of PSA-NCAM in the medial prefrontal cortex. Neuropsychopharmacology. 2007;32(4):803–812. doi: 10.1038/sj.npp.1301183. [DOI] [PubMed] [Google Scholar]
  • 120.Rodríguez JJ, Dallérac GM, Tabuchi M, et al. N-methyl-d-aspartate receptor independent changes in expression of polysialic acid-neural cell adhesion molecule despite blockade of homosynaptic long-term potentiation and heterosynaptic long-term depression in the awake freely behaving rat dentate gyrus. Neuron Glia Biology. 2008;4(3):169–178. doi: 10.1017/S1740925X09990159. [DOI] [PubMed] [Google Scholar]
  • 121.Guiraudie-Capraz G, Chaillan FA, Truchet B, Franc JL, Mourre C, Roman FS. Increase in polysialyltransferase gene expression following LTP in adult rat dentate gyrus. Hippocampus. 2011;21(11):1180–1189. doi: 10.1002/hipo.20835. [DOI] [PubMed] [Google Scholar]
  • 122.Muller D, Mendez P, DeRoo M, Klauser P, Steen S, Poglia L. Role of NCAM in Spine dynamics and synaptogenesis. Advances in Experimental Medicine and Biology. 2010;663:245–256. doi: 10.1007/978-1-4419-1170-4_16. [DOI] [PubMed] [Google Scholar]
  • 123.Grzegorzewska M, Maćkowiak M, Wedzony K, Hess G. 5-HT1A receptors mediate detrimental effects of cocaine on long-term potentiation and expression of polysialylated neural cell adhesion molecule protein in rat dentate gyrus. Neuroscience. 2010;166(1):122–131. doi: 10.1016/j.neuroscience.2009.12.015. [DOI] [PubMed] [Google Scholar]
  • 124.Brezun JM, Daszuta A. Serotonergic reinnervation reverses lesion-induced decreases in PSA-NCAM labeling and proliferation of hippocampal cells in adult rats. Hippocampus. 2000;10(1):37–46. doi: 10.1002/(SICI)1098-1063(2000)10:1<37::AID-HIPO4>3.0.CO;2-C. [DOI] [PubMed] [Google Scholar]
  • 125.Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Research. 2002;109(2):143–148. doi: 10.1016/s0165-1781(02)00005-7. [DOI] [PubMed] [Google Scholar]
  • 126.Shimizu E, Hashimoto K, Okamura N, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biological Psychiatry. 2003;54(1):70–75. doi: 10.1016/s0006-3223(03)00181-1. [DOI] [PubMed] [Google Scholar]
  • 127.Aydemir O, Deveci A, Taneli F. The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2005;29(2):261–265. doi: 10.1016/j.pnpbp.2004.11.009. [DOI] [PubMed] [Google Scholar]
  • 128.Shirayama Y, Chen ACH, Nakagawa S, Russell DS, Duman RS. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. Journal of Neuroscience. 2002;22(8):3251–3261. doi: 10.1523/JNEUROSCI.22-08-03251.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 129.Grønli J, Bramham C, Murison R, et al. Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacology Biochemistry and Behavior. 2006;85(4):842–849. doi: 10.1016/j.pbb.2006.11.021. [DOI] [PubMed] [Google Scholar]
  • 130.Altar CA, Whitehead RE, Chen R, Wörtwein G, Madsen TM. Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biological Psychiatry. 2003;54(7):703–709. doi: 10.1016/s0006-3223(03)00073-8. [DOI] [PubMed] [Google Scholar]
  • 131.Vinet J, Carra S, Blom JMC, Brunello N, Barden N, Tascedda F. Chronic treatment with desipramine and fluoxetine modulate BDNF, CaMKKα and CaMKKβ mRNA levels in the hippocampus of transgenic mice expressing antisense RNA against the glucocorticoid receptor. Neuropharmacology. 2004;47(7):1062–1069. doi: 10.1016/j.neuropharm.2004.07.035. [DOI] [PubMed] [Google Scholar]
  • 132.Russo-Neustadt A, Beard RC, Cotman CW. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology. 1999;21(5):679–682. doi: 10.1016/S0893-133X(99)00059-7. [DOI] [PubMed] [Google Scholar]
  • 133.Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF) Pharmacology Biochemistry and Behavior. 1996;56(1):131–137. doi: 10.1016/S0091-3057(96)00169-4. [DOI] [PubMed] [Google Scholar]
  • 134.Danzer SC, Crooks KRC, Lo DC, McNamara JO. Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures. Journal of Neuroscience. 2002;22(22):9754–9763. doi: 10.1523/JNEUROSCI.22-22-09754.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 135.Seil FJ, Drake-Baumann R. TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis. Journal of Neuroscience. 2000;20(14):5367–5373. doi: 10.1523/JNEUROSCI.20-14-05367.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 136.Li Y, Luikart BW, Birnbaum S, et al. TrkB regulates Hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron. 2008;59(3):399–412. doi: 10.1016/j.neuron.2008.06.023. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 137.Castrén E, Rantamäki T. The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity. Developmental Neurobiology. 2010;70(5):289–297. doi: 10.1002/dneu.20758. [DOI] [PubMed] [Google Scholar]
  • 138.Zörner B, Wolfer DP, Brandis D, et al. Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than ‘depressive’. Biological Psychiatry. 2003;54(10):972–982. doi: 10.1016/s0006-3223(03)00418-9. [DOI] [PubMed] [Google Scholar]
  • 139.Saarelainen T, Hendolin P, Lucas G, et al. Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. Journal of Neuroscience. 2003;23(1):349–357. doi: 10.1523/JNEUROSCI.23-01-00349.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 140.Monteggia LM, Luikart B, Barrot M, et al. Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biological Psychiatry. 2007;61(2):187–197. doi: 10.1016/j.biopsych.2006.03.021. [DOI] [PubMed] [Google Scholar]
  • 141.Muller D, Djebbara-Hannas Z, Jourdain P, et al. Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 2000;97(8):4315–4320. doi: 10.1073/pnas.070022697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 142.Vutskits L, Djebbara-Hannas Z, Zhang H, et al. PSA-NCAM modulates BDNF-dependent survival and differentiation of cortical neurons. European Journal of Neuroscience. 2001;13(7):1391–1402. doi: 10.1046/j.0953-816x.2001.01516.x. [DOI] [PubMed] [Google Scholar]
  • 143.Burgess A, Aubert I. Polysialic acid limits choline acetyltransferase activity induced by brain-derived neurotrophic factor. Journal of Neurochemistry. 2006;99(3):797–806. doi: 10.1111/j.1471-4159.2006.04110.x. [DOI] [PubMed] [Google Scholar]
  • 144.Gascon E, Vutskits L, Jenny B, Durbec P, Kiss JZ. PSA-NCAM in postnatally generated immature neurons of the olfactory bulb: a crucial role in regulating p75 expression and cell survival. Development. 2007;134(6):1181–1190. doi: 10.1242/dev.02808. [DOI] [PubMed] [Google Scholar]
  • 145.Young KM, Merson TD, Sotthibundhu A, Coulson EJ, Bartlett PF. p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells. Journal of Neuroscience. 2007;27(19):5146–5155. doi: 10.1523/JNEUROSCI.0654-07.2007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 146.Catts VS, Al-Menhali N, Burne THJ, Colditz MJ, Coulson EJ. The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours. European Journal of Neuroscience. 2008;28(5):883–892. doi: 10.1111/j.1460-9568.2008.06390.x. [DOI] [PubMed] [Google Scholar]
  • 147.Colditz MJ, Catts VS, Al-Menhali N, Osborne GW, Bartlett PF, Coulson EJ. P75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis. Experimental Brain Research. 2010;200(2):161–167. doi: 10.1007/s00221-009-1947-6. [DOI] [PubMed] [Google Scholar]
  • 148.Gutiérrez-Lobos K, Scherer M, Anderer P, Katschnig H. The influence of age on the female/male ratio of treated incidence rates in depression. BMC Psychiatry. 2002;2(1):p. 3. doi: 10.1186/1471-244X-2-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 149.Kornstein SG, Schatzberg AF, Thase ME, et al. Gender differences in treatment response to sertraline versus imipramine in chronic depression. American Journal of Psychiatry. 2000;157(9):1445–1452. doi: 10.1176/appi.ajp.157.9.1445. [DOI] [PubMed] [Google Scholar]
  • 150.Shores MM, Sloan KL, Matsumoto AM, Moceri VM, Felker B, Kivlahan DR. Increased incidence of diagnosed depressive illness in hypogonadal older men. Archives of General Psychiatry. 2004;61(2):162–167. doi: 10.1001/archpsyc.61.2.162. [DOI] [PubMed] [Google Scholar]
  • 151.Shores MM, Moceri VM, Sloan KL, Matsumoto AM, Kivlahan DR. Low testosterone levels predict incident depressive illness in older men: effects of age and medical morbidity. The Journal of clinical psychiatry. 2005;66(1):7–14. doi: 10.4088/jcp.v66n0102. [DOI] [PubMed] [Google Scholar]
  • 152.Shores MM, Kivlahan DR, Sadak TI, Li EJ, Matsumoto AM. A randomized, double-blind, placebo-controlled study of testosterone treatment in hypogonadal older men with subthreshold depression (dysthymia or minor depression) Journal of Clinical Psychiatry. 2009;70(7):1009–1016. doi: 10.4088/jcp.08m04478. [DOI] [PubMed] [Google Scholar]
  • 153.McIntyre RS, Mancini D, Eisfeld BS, et al. Calculated bioavailable testosterone levels and depression in middle-aged men. Psychoneuroendocrinology. 2006;31(9):1029–1035. doi: 10.1016/j.psyneuen.2006.06.005. [DOI] [PubMed] [Google Scholar]
  • 154.Veras AB, Nardi AE. The complex relationship between hypogonadism and major depression in a young male. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2010;34(2):421–422. doi: 10.1016/j.pnpbp.2009.12.008. [DOI] [PubMed] [Google Scholar]
  • 155.Seidman SN, Rabkin JG. Testosterone replacement therapy for hypogonadal men with SSRI- refractory depression. Journal of Affective Disorders. 1998;48(2-3):157–161. doi: 10.1016/s0165-0327(97)00168-7. [DOI] [PubMed] [Google Scholar]
  • 156.Zarrouf FA, Artz S, Griffith J, Sirbu C, Kommor M. Testosterone and depression: systematic review and meta-analysis. Journal of Psychiatric Practice. 2009;15(4):289–305. doi: 10.1097/01.pra.0000358315.88931.fc. [DOI] [PubMed] [Google Scholar]
  • 157.Pope HG, Jr., Cohane GH, Kanayama G, Siegel AJ, Hudson JI. Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial. American Journal of Psychiatry. 2003;160(1):105–111. doi: 10.1176/appi.ajp.160.1.105. [DOI] [PubMed] [Google Scholar]
  • 158.Seidman SN, Spatz E, Rizzo C, Roose SP. Testosterone replacement therapy for hypogonadal men with major depressive disorder: a randomized, placebo-controlled clinical trial. Journal of Clinical Psychiatry. 2001;62(6):406–412. doi: 10.4088/jcp.v62n0602. [DOI] [PubMed] [Google Scholar]
  • 159.Pope HG, Jr., Amiaz R, Brennan BP, et al. Parallel-group placebo-controlled trial of testosterone gel in men with major depressive disorder displaying an incomplete response to standard antidepressant treatment. Journal of Clinical Psychopharmacology. 2010;30(2):126–134. doi: 10.1097/JCP.0b013e3181d207ca. [DOI] [PubMed] [Google Scholar]
  • 160.Hendrick V, Altshuler LL, Suri R. Hormonal changes in the postpartum and implications for postpartum depression. Psychosomatics. 1998;39(2):93–101. doi: 10.1016/S0033-3182(98)71355-6. [DOI] [PubMed] [Google Scholar]
  • 161.Cohen LS, Soares CN, Vitonis AF, Otto MW, Harlow BL. Risk for new onset of depression during the menopausal transition: the harvard study of moods and cycles. Archives of General Psychiatry. 2006;63(4):385–390. doi: 10.1001/archpsyc.63.4.385. [DOI] [PubMed] [Google Scholar]
  • 162.Rasgon NL, Altshuler LL, Fairbanks LA, et al. Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal women. Journal of Clinical Psychiatry. 2002;63(supplement 7):45–48. [PubMed] [Google Scholar]
  • 163.De Novaes Soares C, Almeida OP, Joffe H, Cohen LS. Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial. Archives of General Psychiatry. 2001;58(6):529–534. doi: 10.1001/archpsyc.58.6.529. [DOI] [PubMed] [Google Scholar]
  • 164.Soares CN, Poitras JR, Prouty J, Alexander AB, Shifren JL, Cohen LS. Efficacy of citalopram as a monotherapy or as an adjunctive treatment to estrogen therapy for perimenopausal and postmenopausal women with depression and vasomotor symptoms. Journal of Clinical Psychiatry. 2003;64(4):473–479. doi: 10.4088/jcp.v64n0419. [DOI] [PubMed] [Google Scholar]
  • 165.Green AD, Galea LAM. Adult hippocampal cell proliferation is suppressed with estrogen withdrawal after a hormone-simulated pregnancy. Hormones and Behavior. 2008;54(1):203–211. doi: 10.1016/j.yhbeh.2008.02.023. [DOI] [PubMed] [Google Scholar]
  • 166.Sell SL, Craft RM, Seitz PK, Stutz SJ, Cunningham KA, Thomas ML. Estradiol-sertraline synergy in ovariectomized rats. Psychoneuroendocrinology. 2008;33(8):1051–1060. doi: 10.1016/j.psyneuen.2008.05.006. [DOI] [PubMed] [Google Scholar]
  • 167.Carrier N, Kabbaj M. Testosterone and imipramine have antidepressant effects in socially isolated male but not female rats. Hormones and Behavior. 2012;61(5):678–685. doi: 10.1016/j.yhbeh.2012.03.001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 168.Spritzer MD, Galea LAM. Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats. Developmental Neurobiology. 2007;67(10):1321–1333. doi: 10.1002/dneu.20457. [DOI] [PubMed] [Google Scholar]
  • 169.Galea LAM, Spritzer MD, Barker JM, Pawluski JL. Gonadal hormone modulation of hippocampal neurogenesis in the adult. Hippocampus. 2006;16(3):225–232. doi: 10.1002/hipo.20154. [DOI] [PubMed] [Google Scholar]
  • 170.Tan O, Fadiel A, Chang A, et al. Estrogens regulate posttranslational modification of neural cell adhesion molecule during the estrogen-induced gonadotropin surge. Endocrinology. 2009;150(6):2783–2790. doi: 10.1210/en.2008-0927. [DOI] [PubMed] [Google Scholar]
  • 171.Hatanaka Y, Mukai H, Mitsuhashi K, et al. Androgen rapidly increases dendritic thorns of CA3 neurons in male rat hippocampus. Biochemical and Biophysical Research Communications. 2009;381(4):728–732. doi: 10.1016/j.bbrc.2009.02.130. [DOI] [PubMed] [Google Scholar]
  • 172.MacLusky NJ, Hajszan T, Johansen JA, Jordan CL, Leranth C. Androgen effects on hippocampal CA1 spine synapse numbers are retained in Tfm male rats with defective androgen receptors. Endocrinology. 2006;147(5):2392–2398. doi: 10.1210/en.2005-0673. [DOI] [PubMed] [Google Scholar]
  • 173.Rasika S, Alvarez-Buylla A, Nottebohm F. BDNF mediates the effects of testosterone on the survival of new neurons in an adult brain. Neuron. 1999;22(1):53–62. doi: 10.1016/s0896-6273(00)80678-9. [DOI] [PubMed] [Google Scholar]
  • 174.Yang LY, Verhovshek T, Sengelaub DR. Brain-derived neurotrophic factor and androgen interact in the maintenance of dendritic morphology in a sexually dimorphic rat spinal nucleus. Endocrinology. 2004;145(1):161–168. doi: 10.1210/en.2003-0853. [DOI] [PubMed] [Google Scholar]
  • 175.Solum DT, Handa RJ. Estrogen regulates the development of Brain-derived neurotrophic factor mRNA and protein in the rat hippocampus. Journal of Neuroscience. 2002;22(7):2650–2659. doi: 10.1523/JNEUROSCI.22-07-02650.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 176.Franklin TB, Perrot-Sinal TS. Sex and ovarian steroids modulate brain-derived neurotrophic factor (BDNF) protein levels in rat hippocampus under stressful and non-stressful conditions. Psychoneuroendocrinology. 2006;31(1):38–48. doi: 10.1016/j.psyneuen.2005.05.008. [DOI] [PubMed] [Google Scholar]
  • 177.Sohrabji F, Miranda RCG, Toran-Allerand CD. Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proceedings of the National Academy of Sciences of the United States of America. 1995;92(24):11110–11114. doi: 10.1073/pnas.92.24.11110. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 178.Murphy DD, Cole NB, Segal M. Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 1998;95(19):11412–11417. doi: 10.1073/pnas.95.19.11412. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 179.Dimberg Y, Vazquez M, Söderström S, Ebendal T. Effects of X-irradiation on nerve growth factor in the developing mouse brain. Toxicology Letters. 1997;90(1):35–43. doi: 10.1016/s0378-4274(96)03827-1. [DOI] [PubMed] [Google Scholar]
  • 180.Casadesus G, Shukitt-Hale B, Stellwagen HM, Smith MA, Rabin BM, Joseph JA. Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats. Experimental Gerontology. 2005;40(3):249–254. doi: 10.1016/j.exger.2004.09.007. [DOI] [PubMed] [Google Scholar]
  • 181.Snyder JS, Choe JS, Clifford MA, et al. Adult-born hippocampal neurons are more numerous, faster maturing, and more involved in behavior in rats than in mice. Journal of Neuroscience. 2009;29(46):14484–14495. doi: 10.1523/JNEUROSCI.1768-09.2009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 182.Marsden WN. Synaptic plasticity in depression: molecular, cellular and functional correlates. Progress in Neuro-Psychopharmacology Biological Psychiatry C. 2012;43:168–184. doi: 10.1016/j.pnpbp.2012.12.012. [DOI] [PubMed] [Google Scholar]
  • 183.Sandi C, Bisaz R. A model for the involvement of neural cell adhesion molecules in stress-related mood disorders. Neuroendocrinology. 2007;85(3):158–176. doi: 10.1159/000101535. [DOI] [PubMed] [Google Scholar]

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