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. 1987 Feb;7(2):932–935. doi: 10.1128/mcb.7.2.932

Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.

M J Sawey, A T Hood, F J Burns, S J Garte
PMCID: PMC365153  PMID: 3547086

Abstract

An activated K-ras oncogene was detected by transfection in NIH 3T3 cells and by Southern blot analysis in 6 of 12 rat skin tumors induced by ionizing radiation. The DNA from 10 of the 12 tumors also showed c-myc gene amplification and restriction polymorphisms. Evidence for tissue specificity was observed in patterns of oncogene activation, with each of three clear cell carcinomas exhibiting activation of both c-myc and K-ras oncogenes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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