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. 1987 Feb;7(2):946–950. doi: 10.1128/mcb.7.2.946

Polyomavirus middle T antigen downregulates junctional cell-to-cell communication.

R Azarnia, W R Loewenstein
PMCID: PMC365156  PMID: 2434836

Abstract

We examined the effect of polyomavirus middle T antigen on cell-to-cell communication in rat F cells transfected with an inducible middle T recombinant DNA or infected with a conditional mutant virus. Junctional permeability fell (reversibly) when middle T transcription was induced or when middle T was switched to the transformation+ form. The effect correlates with the rise of protein tyrosine kinase activity.

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Selected References

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