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. 1987 Apr;7(4):1541–1544. doi: 10.1128/mcb.7.4.1541

Functional simian virus 40 T antigen is expressed in hybrid cells having finite proliferative potential.

O M Pereira-Smith, J R Smith
PMCID: PMC365243  PMID: 3037326

Abstract

Simian virus 40-transformed human cells fused with other independently derived simian virus 40-transformed cells and tumor-derived cells containing activated H-ras and N-ras oncogenes yielded hybrids capable of indefinite division. Fusions with various other immortal cells yielded hybrids that had limited division potential. T antigen expressed in limited-division hybrids was functional for the induction of cellular DNA synthesis.

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Selected References

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