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. 1987 May;7(5):1999–2002. doi: 10.1128/mcb.7.5.1999

Neutralizing monoclonal antibody against ras oncogene product p21 which impairs guanine nucleotide exchange.

S Hattori, D J Clanton, T Satoh, S Nakamura, Y Kaziro, M Kawakita, T Y Shih
PMCID: PMC365309  PMID: 2439901

Abstract

The neutralizing monoclonal antibody Y13-259 severely hampers the nucleotide exchange reaction between p21-bound and exogenous guanine nucleotides but does not interfere with the association of GDP to p21. These results suggest that the nucleotide exchange reaction is critical for p21 function. Interestingly, the v-ras p21 has a much faster dissociation rate than the p21 of the c-ras proto-oncogene.

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1999

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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