Figure 5.

A-F, PD98059 reduced lung stretch-induced microvascular leak, lung edema, neutrophil influx, oxidative stress, and TGF-β1 and MIP-2 production. EBD analysis (A), lung wet weight-to-dry weight ratio (B), MPO assay (C), MDA assay (D), and MIP-2 (E) and TGF-β1 (F) production were from nonventilated control mice and mice ventilated at Vt 30 mL/kg for 8 h with room air (n = 5 per group). PD98059 2 mg/kg was given subcutaneously 30 min before ventilation. P < .05 vs nonventilated control mice; †P < .05 vs PD98059 group. See Figure 1 for expansion of abbreviations.