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. 1987 Jul;7(7):2558–2567. doi: 10.1128/mcb.7.7.2558

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

J L Imler, C Lemaire, C Wasylyk, B Wasylyk
PMCID: PMC365391  PMID: 3039350

Abstract

We have identified in and around the immunoglobulin heavy-chain enhancer two apparently distinct negative regulatory elements which repress immunoglobulin H enhancer, simian virus 40 enhancer, and heterologous promoter activity in fibroblasts but not in myeloma cells. We propose that in nonlymphoid cells, negative regulatory elements prevent activation of the immunoglobulin H enhancer by ubiquitous stimulatory trans-acting factors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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