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. 1987 Jul;7(7):2606–2609. doi: 10.1128/mcb.7.7.2606

Extinction of alpha-fetoprotein gene expression in somatic cell hybrids involves cis-acting DNA elements.

S G Widen, J Papaconstantinou
PMCID: PMC365398  PMID: 2441243

Abstract

alpha-Fetoprotein (AFP), a liver-specific protein, is extinguished in somatic cell hybrids formed by the fusion of mouse hepatoma cells (BWTG3) with rat fibroblast cells (JF1). Our studies show that the extinction of mouse AFP expression in these somatic cell hybrids may involve at least two cis-acting regulatory domains, i.e., the enhancer elements and a tissue-specific promoter region, which are located in the 5'-flanking region of the AFP gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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