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. 1988 Sep;8(9):3943–3946. doi: 10.1128/mcb.8.9.3943

Use of a simian virus 40-based shuttle vector to analyze enhanced mutagenesis in mitomycin C-treated monkey cells.

E Roilides 1, P J Munson 1, A S Levine 1, K Dixon 1
PMCID: PMC365455  PMID: 2851732

Abstract

When monkey cells were treated with mitomycin C 24 h before transfection with UV-irradiated pZ189 (a simian virus 40-based shuttle vector), there was a twofold increase in the frequency of mutations in the supF gene of the vector. These results suggest the existence of an enhancible mutagenesis pathway in mammalian cells. However, DNA sequence analysis of the SupF- mutants suggested no dramatic changes in the mechanisms of mutagenesis due to mitomycin C treatment of the cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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