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. 2013 Feb 27;38(7):1163–1175. doi: 10.1038/npp.2013.35

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Copyright © 2013 American College of Neuropsychopharmacology

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Anhedonia demonstrated using the sucrose preference test (SPT). (a) Sucrose preference of animals in the 12-h light, 12-h dark (LD), continuous darkness (DD), photoreceptor ablation-DD-vehicle (MNU-DD-VEH-3), and MNU-DD-anti-cholera toxin subunit B saporin immunotoxin (MNU-anti-CTB-SAP) groups. Animals had decreased sucrose preferences after light deprivation, which could be reversed by MNU treatment. Sucrose preference of animals in MNU-DD group decreased significantly after intravitreal anti-CTB-SAP treatment. LD group serves as control. One-way ANOVA; *p<0.05; **p<0.001. (b) Sucrose preference of animals in the DD-VEH-2, DD-fluoxetine (DD-FLX), and DD-imipramine hydrochloride (DD-IMI) groups. Sucrose preference of animals in the DD group elevated significantly after FLX/IMI chronic treatment. DD-VEH-2 group serves as control. One-way ANOVA; *p<0.05. Total intake of liquid (tap water plus sucrose solution) was unchanged between the groups (one-way ANOVA, F_5,24=0.58, p=0.72; Supplementary Figure S4). Results are presented as mean of sucrose preference (the percentage of sucrose solution ingested relative to the total amount of liquid consumed)±SEM.