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. 1988 Dec;8(12):5549–5554. doi: 10.1128/mcb.8.12.5549

The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.

E B Jakobovits 1, U Schlokat 1, J L Vannice 1, R Derynck 1, A D Levinson 1
PMCID: PMC365660  PMID: 2907605

Abstract

Transforming growth factor alpha (TGF-alpha) is a transformation-responsive mitogenic polypeptide that is expressed in the brain, epithelial cells, and activated macrophages. We isolated and characterized the TGF-alpha promoter and localized the 5' end of the TGF-alpha transcript to a unique position. Surprisingly, no apparent TATA box was present in the promoter sequence, suggesting that transcription from mammalian genes can initiate at unique and specific positions from promoters lacking this sequence motif.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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