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ATRA is able to extend survival of PML-RARα and PML-RARα + Sox4 secondary transplanted mice. Kaplan-Meier survival curves of secondary transplanted animals with placebo or ATRA pellet implantation. Compared to their respective placebo controls, ATRA is able to significantly extend survival in PML-RARα mice (2.3fold difference in median survival; P=0.0052) as well as in PML-RARα + Sox4 mice (1.6-fold difference in median survival; P=0.0038).
