Abstract
The sterol composition of C. ellipsoidea was markedly changed when this alga was grown in the presence of 1 μg/g triparanol. Triparanol appears to inhibit the removal of 14α-methyl group, the second alkylation at C-24, Δ7-reductase, and Δ8 → Δ7-isomerase. The effect of triparanol in Chlorella is much more diversified than the specific effect originally assigned to it in animals.
Full text
PDF

Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AVIGAN J., STEINBERG D., VROMAN H. E., THOMPSON M. J., MOSETTIG E. Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29. J Biol Chem. 1960 Nov;235:3123–3126. [PubMed] [Google Scholar]
- Aaronson S., Bensky B. Study of the cellular action of drugs with protozoa. II. Comparative study of the inhibitions induced by hypocholesteremic agents on Ochromonas danica multiplication; annulment by oleic acid. J Protozool. 1965 May;12(2):236–240. doi: 10.1111/j.1550-7408.1965.tb01843.x. [DOI] [PubMed] [Google Scholar]
- CLAYTON R. B., NELSON A. N., FRANTZ I. D., Jr THE SKIN STEROLS OF NORMAL AND TRIPARANOL-TREATED RATS. J Lipid Res. 1963 Apr;4:166–176. [PubMed] [Google Scholar]
- Dempsey M. E. Inhibition of lipid biosynthesis. Ann N Y Acad Sci. 1968 Mar 26;148(3):631–646. doi: 10.1111/j.1749-6632.1968.tb27737.x. [DOI] [PubMed] [Google Scholar]
- HOLMES W. L., DITULLIO N. W. Inhibitors of cholesterol biosynthesis which act at or beyond the mevalonic acid stage. Am J Clin Nutr. 1962 Apr;10:310–322. doi: 10.1093/ajcn/10.4.310. [DOI] [PubMed] [Google Scholar]
- Otto H. F. Tierexperimentelle Untersuchungen zur Hepato-"Toxizität" von Triparanol. Beitr Pathol. 1971 Feb;142(2):177–193. [PubMed] [Google Scholar]
- Patterson G. W. Sterols of Chlorella. II. The Occurrence of an Unusual Sterol Mixture in Chlorella vulgaris. Plant Physiol. 1967 Oct;42(10):1457–1459. doi: 10.1104/pp.42.10.1457. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vroman H. E., Cohen C. F. Separation of sterol acetates by column and thin-layer argentation chromatography. J Lipid Res. 1967 Mar;8(2):150–152. [PubMed] [Google Scholar]
