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. 1985 Apr;5(4):881–884. doi: 10.1128/mcb.5.4.881

DNA-mediated transfer of a human DNA repair gene that controls sister chromatid exchange.

L H Thompson, K W Brookman, J L Minkler, J C Fuscoe, K A Henning, A V Carrano
PMCID: PMC366793  PMID: 3990694

Abstract

The Chinese hamster cell line mutant EM9, which has a reduced ability to repair DNA strand breaks, is noted for its highly elevated frequency of sister chromatid exchange, a property shared with cells from individuals with Bloom's syndrome. The defect in EM9 cells was corrected by fusion hybridization with normal human fibroblasts and by transfection with DNA from hybrid cells. The transformants showed normalization of sister chromatid exchange frequency but incomplete correction of the repair defect in terms of chromosomal aberrations produced by 5-bromo-2'-deoxyuridine.

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Selected References

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