The challenge of increasing Pfam coverage of the human proteome

Two percentage values reported in this article were inadvertently misreported.

In the ‘Abstract’ section, the sentence ‘Thirty-four per cent of regions, on the other hand, matched fewer than 100 sequences in UniProtKB.’ should read, ‘Forty-six per cent of regions, on the other hand, matched fewer than 100 sequences in UniProtKB.’

Additionally, in the main text of the article, the sentence, ‘Almost 2/3 of the clusters that we identified that account for 34% of all uncovered regions, however, appear to have only a small number of homologous regions in UniProtKB …’ should read, ‘Almost 2/3 of the clusters that we identified that account for 44% of all uncovered regions, however, appear to have only a small number of homologous regions in UniProtKB …’

The authors wish to apologize for these imprecisions. The 34% that was originally reported corresponds to the percentage of regions that match <100 sequences in UniProtKB and additionally appear not to share any relationship with existing Pfam-A families. This was erroneously reported as the percentage of regions that match <100 sequences in UniProtKB (in the ‘Abstract’ section) and the percentage of regions in clusters with a mean number of homologous regions in UniProtKB that is <100 (in the main text).

The authors believe that these changes do not affect the main conclusions of the article.