Abstract
Polyclonal and monoclonal antibodies with specificity for protein Mx (a karyophilic 75,000-dalton protein induced by interferon [IFN] in mouse cells carrying the influenza virus resistance allele Mx+) detected an IFN-induced 80,000-dalton protein in peripheral blood lymphocytes and in fibroblasts of healthy human donors. The human protein, like protein Mx, was induced by IFN-alpha but not by IFN-gamma. Unlike the mouse protein, it was predominantly localized in the cell cytoplasm.
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Selected References
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- Cheng Y. S., Colonno R. J., Yin F. H. Interferon induction of fibroblast proteins with guanylate binding activity. J Biol Chem. 1983 Jun 25;258(12):7746–7750. [PubMed] [Google Scholar]
- Dreiding P., Staeheli P., Haller O. Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses. Virology. 1985 Jan 15;140(1):192–196. doi: 10.1016/0042-6822(85)90460-x. [DOI] [PubMed] [Google Scholar]
- Haller O., Arnheiter H., Gresser I., Lindenmann J. Virus-specific interferon action. Protection of newborn Mx carriers against lethal infection with influenza virus. J Exp Med. 1981 Jul 1;154(1):199–203. doi: 10.1084/jem.154.1.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haller O. Inborn resistance of ice to orthomyxoviruses. Curr Top Microbiol Immunol. 1981;92:25–52. doi: 10.1007/978-3-642-68069-4_3. [DOI] [PubMed] [Google Scholar]
- Horisberger M. A., Staeheli P., Haller O. Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus. Proc Natl Acad Sci U S A. 1983 Apr;80(7):1910–1914. doi: 10.1073/pnas.80.7.1910. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lengyel P. Biochemistry of interferons and their actions. Annu Rev Biochem. 1982;51:251–282. doi: 10.1146/annurev.bi.51.070182.001343. [DOI] [PubMed] [Google Scholar]
- Rubin B. Y., Gupta S. L. Differential efficacies of human type I and type II interferons as antiviral and antiproliferative agents. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5928–5932. doi: 10.1073/pnas.77.10.5928. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Staeheli P., Dreiding P., Haller O., Lindenmann J. Polyclonal and monoclonal antibodies to the interferon-inducible protein Mx of influenza virus-resistant mice. J Biol Chem. 1985 Feb 10;260(3):1821–1825. [PubMed] [Google Scholar]
- Staeheli P., Horisberger M. A., Haller O. Mx-dependent resistance to influenza viruses is induced by mouse interferons alpha and beta but not gamma. Virology. 1984 Jan 30;132(2):456–461. doi: 10.1016/0042-6822(84)90050-3. [DOI] [PubMed] [Google Scholar]
- Staeheli P., Prochazka M., Steigmeier P. A., Haller O. Genetic control of interferon action: mouse strain distribution and inheritance of an induced protein with guanylate-binding property. Virology. 1984 Aug;137(1):135–142. doi: 10.1016/0042-6822(84)90016-3. [DOI] [PubMed] [Google Scholar]
- Weil J., Epstein C. J., Epstein L. B., Sedmak J. J., Sabran J. L., Grossberg S. E. A unique set of polypeptides is induced by gamma interferon in addition to those induced in common with alpha and beta interferons. Nature. 1983 Feb 3;301(5899):437–439. doi: 10.1038/301437a0. [DOI] [PubMed] [Google Scholar]
- Wilson V., Jeffreys A. J., Barrie P. A., Boseley P. G., Slocombe P. M., Easton A., Burke D. C. A comparison of vertebrate interferon gene families detected by hybridization with human interferon DNA. J Mol Biol. 1983 Jun 5;166(4):457–475. doi: 10.1016/s0022-2836(83)80281-2. [DOI] [PubMed] [Google Scholar]