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. 2012 Jan 1;1(1):34–43. doi: 10.4161/jkst.18006

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Copyright © 2012 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name jkst-1-34-g1.jpg — Figure 1. STAT phosphorylation as a reporter for regulatory factors. (A) Antibodies detecting pSTAT1 and STAT1 (top two panels) as well as pSTAT3 and STAT3 (bottom 3 panels) were used to assess the effect of stimulation with the cytokines shown. (B) The effect of the indicated siRNAs on the levels of pSTAT1 and total STAT1 following IFN-γ stimulation as indicated. Note the loss of STAT1 following treatment with STAT1 siRNA and the reduction in pSTAT1 levels following knockdown with JAK1 siRNA. (C) The effect of the indicated siRNAs on the levels of pSTAT3 and total STAT3 following OSM stimulation as indicated. (D and E) The effect of the indicated siRNAs on the levels of pSTAT1 and total STAT1 following IFN-γ stimulation (D) and pSTAT3 and STAT3 following OSM stimulation (E).