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. 2012 Jan 1;1(1):34–43. doi: 10.4161/jkst.18006

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Copyright © 2012 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name jkst-1-34-g2.jpg — Figure 2. Assays for STAT-mediated transcriptional regulation. (A) Fold increase in the mRNA levels of the indicated putative STAT target genes following stimulation with the indicated ligands. (B) Fold increase in the mRNA levels of GBP1 (black bars) and SOCS3 (gray bars) following stimulation with IFN-γ and OSM respectively. Cells were previously treated with the indicated siRNAs targeting known JAK-STAT pathway components and demonstrate the specificity of these target genes for STAT1 and STAT3 as well as the compensatory effects that result from the knockdown of other related factors. Statistical significance is indicated by **p < 0.01, ***p < 0.001. Error bars show standard error.