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. 1985 Oct;5(10):2847–2850. doi: 10.1128/mcb.5.10.2847

v-src inhibits differentiation via an extracellular intermediate(s).

P R Langer-Safer, S R Lehrman, A M Skalka
PMCID: PMC367025  PMID: 3939255

Abstract

Murine 3T3L1 preadipocytes transformed by avian sarcoma virus were unable to differentiate in response to insulin or dexamethasone plus 1-methyl-3-isobutylxanthine, both potent inducers of differentiation of the nontransformed 3T3L1 parental line. Conditioned medium from transformed cells contained a relatively heat-stable factor(s) which inhibited the differentiation of untransformed parental 3T3L1 cells but did not induce any changes in their morphology. A protease-sensitive mitogen was also detected in the medium. The relationship between the two activities remains to be elucidated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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