Table 5.

ACC metabolite concentrations and ratios in A-B and SCI-noNP, SCI-HPI, and SCI-LPI groups.

Metabolites	A-B (n = 22) Mean ± SEM	SCI-noNP (n = 14) Mean ± SEM	SCI-LPI (n = 24) Mean ± SEM	SCI-HPI (n = 16) Mean ± SEM	ANOVA F; P value
NAA	6.21 ± 0.12	6.22 ± 0.14	6.04 ± 0.16	6.18 ± 0.10	0.422; .738
Ins	5.37 ± 0.09	5.65 ± 0.15	5.12 ± 0.11	5.75 ± 0.10	6.700; .000*
Glx	7.95 ± 0.22	8.28 ± 0.46	7.59 ± 0.22	7.22 ± 0.24	2.258; .089†
Cr	5.07 ± 0.39	5.29 ± 0.41	4.95 ± 0.48	5.35 ± 0.25	4.139; .009‡
Cho	1.45 ± 0.17	1.46 ± 0.09	1.42 ± 0.20	1.56 ± 0.12	2.945; .039§
NAA/Ins	1.16 ± 0.02	1.11 ± 0.03	1.18 ± 0.03	1.08 ± 0.02	2.964; .038||
GLX/Ins	1.48 ± 0.04	1.46 ± 0.07	1.49 ± 0.04	1.26 ± 0.05	4.712; .005¶

A-B = able-bodied control subjects; Cho = choline; Cr = creatine; Glx = glutamate and glutamine; Ins = myoinositol; NAA = N-acetyl aspartate; SCI-HPI = spinal cord injury with high pain impact; SCI-LPI = spinal cord injury with low pain impact; SCI-noNP = spinal cord injury without neuropathic pain.

Post hoc Dunnett test comparing the SCI-HPI group with AB or SCI-noNP, and SCI-LPI:

^*the SCI-HPI group had significantly higher Ins concentrations than SCI-LPI (P < .000) and higher although not significantly (P = .056) than the A-B group;

^†the SCI-HPI group had significantly lower concentrations of Glx (P = .050) than the SCI-noNP group;

^‡the SCI-HPI group had significantly higher concentrations of Cr (P = .007) than SCI-LPI, and higher although not significantly (P = .084) than the A-B group;

^§the SCI-HPI group had significantly higher concentrations of Cho (P = .014) than SCI-LPI, and lower although not significantly (P = .070) than the A-B group;

^||the SCI-HPI group had significantly (P = .024) lower NAA/Ins ratio than the SCI-LPI group;

^¶the SCI-HPI group had significantly lower Glx/Ins ratio than SCI-LPI (P = .003), A-B (P = .006), and SCI-noNP groups (P = .026).