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. 1986 Sep;6(9):3291–3294. doi: 10.1128/mcb.6.9.3291

rasH mutants deficient in GTP binding.

C J Der, B T Pan, G M Cooper
PMCID: PMC367069  PMID: 3097518

Abstract

Single amino acid substitutions were introduced into a region of the rasH protein (residues 116, 117, and 119) homologous to a variety of diverse GTP-binding proteins. Each of the mutant p21 proteins displayed a significant reduction (10- to 5,000-fold) in GTP binding affinity. Activated rasH proteins deficient in GTP binding were unaltered in their ability to morphologically transform NIH 3T3 cells.

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Selected References

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