Table 2.
Summary of pharmacokinetic parameters of THC, CBD and 11-OH-THC after a single dose of THC/CBD (4 sprays) alone or in combination with ketoconazole
| Parameter | THC/CBD spray alone (n = 12) | THC/CBD spray and ketoconazole (n = 11) |
|---|---|---|
| THC | ||
| AUC(0-t) (h*ng/mL) | 8.19 (5.67) | 15.38 (13.43) |
| AUC(0-inf) (h*ng/mL) | 9.22 (5.94)a | 16.76 (13.80) |
| Cmax (ng/mL) | 2.65 (1.32) | 3.36 (1.65) |
| Tmax (h) | 1.50 (0.75-6.00) | 1.75 (1.00-3.00) |
| Kel (h-1) | 0.258 (0.092)a | 0.189 (0.078) |
| t½ (h) | 3.07 (1.31)a | 4.43 (2.19) |
| CL/F (L/h) | 1504 (688)a | 920 (450) |
| Varea/F (L) | 6328 (4164)a | 5111 (2221) |
| CBD | ||
| AUC(0-t) (h*ng/mL) | 1.82 (1.03) | 4.83 (2.01) |
| AUC(0-inf) (h*ng/mL) | 3.54 (0.80)b | 6.50 (2.23)c |
| Cmax (ng/mL) | 0.66 (0.37) | 1.25 (0.51) |
| Tmax (h) | 1.38 (0.75-6.00) | 1.75 (1.00-2.52) |
| Kel (h-1) | 0.122 (0.111)b | 0.143 (0.066)c |
| t½ (h) | 7.81 (3.00)b | 6.54 (4.59)c |
| CL/F (L/h) | 2998 (896)b | 1731 (650)c |
| Varea/F (L) | 31994 (12794)b | 14349 (7076)c |
| 11-OH-THC | ||
| AUC(0-t) (h*ng/mL) | 21.78 (11.34) | 84.34 (40.18) |
| AUC(0-inf) (h*ng/mL) | 27.13 (13.34)d | 95.26 (48.93) |
| Cmax (ng/mL) | 3.59 (1.67) | 10.92 (3.83) |
| Tmax (h) | 1.50 (1.00-6.00) | 2.25 (1.50-4.13) |
| Kel (h-1) | 0.076 (0.014)d | 0.095 (0.016) |
| t½ (h) | 9.51 (2.18)d | 7.48 (1.39) |
Data presented are mean and (SD) except for Tmax where median and range are shown, a n=11; bn=9; cn=10; dn=11.