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. 1986 Nov;6(11):4130–4132. doi: 10.1128/mcb.6.11.4130

In vivo competition of delta-crystallin gene expression by DNA fragments containing a GC box.

S Hayashi, H Kondoh
PMCID: PMC367184  PMID: 3025636

Abstract

Expression of the chicken delta-crystallin gene 1 injected into the nuclei of mouse cells is lens specific. Coinjection of GC box-containing DNA fragments from delta-crystallin, simian virus 40 early, and herpes simplex virus type 1 tk promoters effectively suppressed delta-crystallin expression in the lens, but coinjection with DNA fragments not containing the GC box did not. This suppression was likely due to the competition of an Sp1-like transcription factor(s) and indicates involvement of the apparently ubiquitous factor(s) in the tissue-specific expression of the delta-crystallin gene.

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Selected References

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