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. 2002 Aug 16;27(1):60–64. doi: 10.1007/s00264-002-0390-0

Treatment of painful peripheral neuromas by vein implantation

Ryosuke Kakinoki 1, Ryosuke Ikeguchi 1, Taiichi Matsumoto 1, Makoto Shimizu 1, Takashi Nakamura 1
PMCID: PMC3673692  PMID: 12582812

Abstract.

Firstly, we designed a vein-implantation model using the rat femoral nerve and vein to study the morphometric changes in nerve endings inserted into venous lumina. By 4 weeks, nerve fibers had extended from the nerve stump into the lumen of the vein and along the endothelium of the vein. After 8 weeks, the lengths and number of nerve fibres extending into the vein lumen began to decrease. At 12 weeks, the nerve ending had developed a hemispherical shape. In none of the experiments was a neuroma formed. Secondly, we treated ten neuromas in ten patients by the vein-implantation method. We obtained excellent results in seven patients.

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