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. 1986 Jan;6(1):195–200. doi: 10.1128/mcb.6.1.195

Inheritance of DNA methylation in Coprinus cinereus.

M E Zolan, P J Pukkila
PMCID: PMC367498  PMID: 3785146

Abstract

We examined the inheritance of 5-methylcytosine residues at a centromere-linked locus in the basidiomycete Coprinus cinereus. Although methylated and unmethylated tracts were inherited both mitotically and meiotically the lengths of these tracts were variable. This variation was not confined to any one phase of the life cycle of the organism, and it usually involved the simultaneous de novo methylation of at least four HpaII-MspI sites. We also found that the higher levels of methylation at this locus were transmitted through meiosis, regardless of the level of methylation of the homologous chromosome.

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Selected References

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  1. Antequera F., Tamame M., Villanueva J. R., Santos T. DNA methylation in the fungi. J Biol Chem. 1984 Jul 10;259(13):8033–8036. [PubMed] [Google Scholar]
  2. Bird A. P., Southern E. M. Use of restriction enzymes to study eukaryotic DNA methylation: I. The methylation pattern in ribosomal DNA from Xenopus laevis. J Mol Biol. 1978 Jan 5;118(1):27–47. doi: 10.1016/0022-2836(78)90242-5. [DOI] [PubMed] [Google Scholar]
  3. Dutta S. K., Ojha M. Relatedness between major taxonomic groups of fungi based on the measurement of DNA nucleotide sequence homology. Mol Gen Genet. 1972;114(3):232–240. doi: 10.1007/BF01788892. [DOI] [PubMed] [Google Scholar]
  4. Groudine M., Conkin K. F. Chromatin structure and de novo methylation of sperm DNA: implications for activation of the paternal genome. Science. 1985 May 31;228(4703):1061–1068. doi: 10.1126/science.2986289. [DOI] [PubMed] [Google Scholar]
  5. Holliday R., Pugh J. E. DNA modification mechanisms and gene activity during development. Science. 1975 Jan 24;187(4173):226–232. [PubMed] [Google Scholar]
  6. Huxsoll D. L., Pollard M. Isolation of a poxvirus from stock type 12 adenovirus. Nature. 1966 Mar 12;209(5028):1157–1157. doi: 10.1038/2091157a0. [DOI] [PubMed] [Google Scholar]
  7. Kaput J., Sneider T. W. Methylation of somatic vs germ cell DNAs analyzed by restriction endonuclease digestions. Nucleic Acids Res. 1979 Dec 20;7(8):2303–2322. doi: 10.1093/nar/7.8.2303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Marinus M. G., Carraway M., Frey A. Z., Brown L., Arraj J. A. Insertion mutations in the dam gene of Escherichia coli K-12. Mol Gen Genet. 1983;192(1-2):288–289. doi: 10.1007/BF00327681. [DOI] [PubMed] [Google Scholar]
  9. Razin A., Riggs A. D. DNA methylation and gene function. Science. 1980 Nov 7;210(4470):604–610. doi: 10.1126/science.6254144. [DOI] [PubMed] [Google Scholar]
  10. Saghai-Maroof M. A., Soliman K. M., Jorgensen R. A., Allard R. W. Ribosomal DNA spacer-length polymorphisms in barley: mendelian inheritance, chromosomal location, and population dynamics. Proc Natl Acad Sci U S A. 1984 Dec;81(24):8014–8018. doi: 10.1073/pnas.81.24.8014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Shmookler Reis R. J., Goldstein S. Variability of DNA methylation patterns during serial passage of human diploid fibroblasts. Proc Natl Acad Sci U S A. 1982 Jul;79(13):3949–3953. doi: 10.1073/pnas.79.13.3949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Vanyushin B. F., Tkacheva S. G., Belozersky A. N. Rare bases in animal DNA. Nature. 1970 Mar 7;225(5236):948–949. doi: 10.1038/225948a0. [DOI] [PubMed] [Google Scholar]
  13. Waalwijk C., Flavell R. A. MspI, an isoschizomer of hpaII which cleaves both unmethylated and methylated hpaII sites. Nucleic Acids Res. 1978 Sep;5(9):3231–3236. doi: 10.1093/nar/5.9.3231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wolf S. F., Jolly D. J., Lunnen K. D., Friedmann T., Migeon B. R. Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation. Proc Natl Acad Sci U S A. 1984 May;81(9):2806–2810. doi: 10.1073/pnas.81.9.2806. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wolf S. F., Migeon B. R. Studies of X chromosome DNA methylation in normal human cells. Nature. 1982 Feb 25;295(5851):667–671. doi: 10.1038/295667a0. [DOI] [PubMed] [Google Scholar]

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