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. 1986 May;6(5):1706–1710. doi: 10.1128/mcb.6.5.1706

Nucleotide sequence of the two rat cellular rasH genes.

M Ruta, R Wolford, R Dhar, D Defeo-Jones, R W Ellis, E M Scolnick
PMCID: PMC367698  PMID: 3023901

Abstract

We present the nucleotide sequence of the coding region of the rat c-rasH-1 gene and a partial sequence analysis of the rat c-rasH-2 gene. By comparing these sequences with the Harvey murine sarcoma virus ras gene, we predict that the p21 protein encoded by the Harvey virus differs from the cellular c-rasH-1-encoded p21 at only two amino acids; those at positions 12 and 59. Alterations at each of these positions may play a role in activating the viral p21 protein. The c-rasH-2 gene is likely to be a nonfunctional pseudogene because it lacks introns, cannot be activated to transform NIH 3T3 cells, and differs in sequence from both c-rasH-1 and v-rasH at several base pair positions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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