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. 1986 May;6(5):1847–1850. doi: 10.1128/mcb.6.5.1847

Phorbol ester induces c-sis gene transcription in stem cell line K-562.

O R Colamonici, J B Trepel, C A Vidal, L M Neckers
PMCID: PMC367717  PMID: 3466024

Abstract

The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced megakaryoblastic differentiation and c-sis expression in the human hematopoietic stem cell line K-562. This induction occurred at the transcriptional level, as determined by a nuclear runoff transcriptional assay, and was not a generalized effect of TPA, since the treatment of other hematopoietic cell lines and normal peripheral blood lymphocytes with TPA did not result in the appearance of c-sis mRNA.

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Selected References

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