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Superposition of the structures of the E2~SUMO thioester conjugate from the last 50 ns of simulations in the absence (A) and presence (B) of the E3. A structure from every 5 ns was taken for the superposition. The superposition minimized the root-mean-square-deviation of the E2 only; thus fluctuation in the SUMO structures reflects variations in the relative positioning between the two proteins in the thioester conjugate.
