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. 1986 Jun;6(6):2249–2252. doi: 10.1128/mcb.6.6.2249

Enhancer sequences responsible for DNase I hypersensitivity in polyomavirus chromatin.

P N Bryan, W R Folk
PMCID: PMC367766  PMID: 3023924

Abstract

DNase I preferentially cleaves polyomavirus minichromosomes at two sites in the enhancer, each of which comprises the sequence AAGCAPuPuAAG flanked by short inverted repeats. A tandem duplication of this sequence generates an additional hypersensitive locus. Mutations which alter either the AAGCAPuPuAAG or flanking repeats diminish hypersensitivity. This region must determine the chromatin conformation recognized by DNase I.

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Selected References

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