Table 3.

Ingenuity pathways significantly enriched for differentially expressed genes in module 3 and module 5

Ingenuity Canonical Pathways	Label	FDR (B-H p-value)
P13K/AKT Signaling	Module 3 vs all	0.0176
Regulation of eIF4 and p70S6K Signaling	Module 3 vs all	0.0203
Molecular Mechanisms of Cancer	Module 3 vs all	0.0324
mTOR Signaling	Module 3 vs all	0.0324
Neuregulin Signaling	Module 3 vs all	0.0412
Apoptosis Signaling	Module 3 vs all	0.0412
IGF-1 Signaling	Module 3 vs all	0.0420
Amyloid Processing	Module 3 vs all	0.0425
Cleavage and Polyadenylation of Pre-mRNA	Module 3 vs all	0.0425
JAK/Stat Signaling	Module 3 vs all	0.0499
EIF2 Signaling	Module 5 vs all	0.0002
Leukocyte Extravasation Signaling*	Module 5 vs all	0.0009
RhoGDI Signaling	Module 5 vs all	0.0015
mTOR Signaling	Module 5 vs all	0.0015
Androgen Signaling	Module 5 vs all	0.0015
Huntington’s Disease Signaling	Module 5 vs all	0.0015
Sertoli Cell-Sertoli Cell Junction Signaling	Module 5 vs all	0.0015
Mitochondrial Dysfunction	Module 5 vs all	0.0015
Ephrin Receptor Signaling	Module 5 vs all	0.0016
CXCR4 Signaling*	Module 5 vs all	0.0017
RhoA Signaling	Module 5 vs all	0.0017
Regulation of Actin-based Motility by Rho*	Module 5 vs all	0.0017
Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes*	Module 5 vs all	0.0018
Gap Junction Signaling	Module 5 vs all	0.0018
Breast Cancer Regulation by Stathmin1	Module 5 vs all	0.0018
Axonal Guidance Signaling	Module 5 vs all	0.0018
Regulation of eIF4 and p70S6K Signaling	Module 5 vs all	0.0018
Molecular Mechanisms of Cancer	Module 5 vs all	0.0026
α-Adrenergic Signaling	Module 5 vs all	0.0028
Tight Junction Signaling	Module 5 vs all	0.0032
fMLP Signaling in Neutrophils	Module 5 vs all	0.0052
Cell Cycle: G1/S Checkpoint Regulation	Module 5 vs all	0.0052
Phospholipase C Signaling	Module 5 vs all	0.0052
Signaling by Rho Family GTPases	Module 5 vs all	0.0058
Oxidative Phosphorylation	Module 5 vs all	0.0063
Germ Cell-Sertoli Cell Junction Signaling*	Module 5 vs all	0.0068
Mismatch Repair in Eukaryotes	Module 5 vs all	0.0078
Mechanisms of Viral Exit from Host Cells	Module 5 vs all	0.0093
Antiproliferative Role of TOB in T Cell Signaling	Module 5 vs all	0.0093
NRF2-mediated Oxidative Stress Response*	Module 5 vs all	0.0172
Semaphorin Signaling in Neurons*	Module 5 vs all	0.0221
N-Glycan Biosynthesis*	Module 5 vs all	0.0499

^*Pathways identical with the ones that enriched in differentially expressed genes between preeclamptic and normal placentas in our previous report [6]