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. 1986 Jul;6(7):2716–2720. doi: 10.1128/mcb.6.7.2716

Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine.

S Sukumar, A Perantoni, C Reed, J M Rice, M L Wenk
PMCID: PMC367829  PMID: 3785207

Abstract

Administration of methyl(methoxymethyl)nitrosamine to newborn Fischer 344 rats results in the preferential induction of renal tumors arising from the mesenchymal component of the kidney. DNA from a significant proportion of these tumors was capable of transforming NIH/3T3 cells. This report describes the renal tumor model, the detection of two different ras transforming genes in the kidney tumors (the N-ras oncogene in 1 and K-ras oncogene in 10 kidney tumors) and the characterization of DNA sequences specifying the transformed phenotype.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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