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. 1987 Sep;7(9):3199–3204. doi: 10.1128/mcb.7.9.3199

A Podospora anserina longevity mutant with a temperature-sensitive phenotype for senescence.

M S Turker 1, J G Nelson 1, D J Cummings 1
PMCID: PMC367955  PMID: 3670311

Abstract

A Podospora anserina longevity mutant was identified with a temperature-sensitive phenotype for senescence. This mutant, termed TS1, grew for over 3 m at 27 degrees C, but when shifted to 34 degrees C, it underwent senescence between 10 and 18 cm. A previously described senescence-associated plasmid, alpha senDNA, derived from the mitochondrial genome, was not detected in TS1 at 27 degrees C but was present in senescent cultures at 34 degrees C. A similar result was observed in progeny strains obtained by crossing the TS1 mutant with a wild-type strain. Other mitochondrial excision-amplification DNAs in addition to alpha senDNA were also observed in the senescent cultures. Most were derived from a specific region of the mitochondrial genome. These results provide evidence that alpha senDNA is involved in TS1 senescence and suggest that this plasmid may play a role in the formation of other mitochondrial excision-amplification plasmids.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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