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. 1987 Sep;7(9):3332–3336. doi: 10.1128/mcb.7.9.3332

Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.

E J Lewis 1, D M Chikaraishi 1
PMCID: PMC367973  PMID: 2890099

Abstract

The addition of epidermal growth factor (EGF) to cultures of the rat PCG2 pheochromocytoma cell line increased the level of RNA coding for tyrosine hydroxylase (TH). A region of DNA containing 5'-flanking sequences of the TH gene was fused to a heterologous gene and transfected into a rat anterior pituitary cell line, GH4. The TH gene sequences from +27 to -272 contained information sufficient for the induction of TH by EGF. Two regions within this TH DNA were extensively homologous to the EGF regulatory element of the rat prolactin gene.

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Selected References

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