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. 1987 Sep;7(9):3349–3352. doi: 10.1128/mcb.7.9.3349

A burst of c-fos gene expression in the mouse occurs at birth.

J W Kasik 1, Y J Wan 1, K Ozato 1
PMCID: PMC367977  PMID: 3313015

Abstract

Expression of the c-fos gene during murine perinatal development was studied. Before birth, all eight of the prenatal organs tested expressed undetectable or low levels of c-fos mRNA. On the day of birth, there occurred a 10- to 100-fold increase in the level of c-fos message in all of these organs. The expression was transient, in that 1 day after birth, the level of c-fos mRNA precipitously dropped. The c-fos gene expression at birth is unrelated to the expression of the c-myc gene and major histocompatibility complex class I genes, which display distinct kinetics during the perinatal development. The c-fos gene was also expressed locally and transiently in the gravid uterus 1 to 2 days prior to delivery. These results indicate that an event associated with birth induced c-fos gene expression in the mother and newborn.

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Selected References

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