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. 1987 Dec;7(12):4564–4567. doi: 10.1128/mcb.7.12.4564

Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.

W D Schleuning 1, R L Medcalf 1, C Hession 1, R Rothenbühler 1, A Shaw 1, E K Kruithof 1
PMCID: PMC368144  PMID: 3325828

Abstract

We have isolated and sequenced two cDNA clones coding for plasminogen activator inhibitor 2 (PAI-2). The cDNA was used to study the regulation of PAI-2 gene transcription by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate in the human histiocytic lymphoma cell line U-937. The tumor promoter caused a transient, 50-fold increase of PAI-2 gene transcription.

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Selected References

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