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. 1987 Dec;7(12):4582–4584. doi: 10.1128/mcb.7.12.4582

RNA polymerase II transcription factors H4TF-1 and H4TF-2 require metal to bind specific DNA sequences.

L Dailey 1, S B Roberts 1, N Heintz 1
PMCID: PMC368148  PMID: 3437898

Abstract

Specific DNA-binding and in vitro transcription activities of H4TF-1 and H4TF-2 are inactivated by chelating agents. Binding activity is restored by addition of Zn2+, and H4TF-2 is also reactivated by Fe2+. In contrast, preformed factor-DNA complexes are resistant to chelators. Therefore, metal ions are a required component of the H4TF-1 and H4TF-2 DNA-binding domains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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