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. 1987 Dec;7(12):4585–4588. doi: 10.1128/mcb.7.12.4585

Specific mRNA destabilization in Dictyostelium discoideum requires RNA synthesis.

J F Amara 1, H F Lodish 1
PMCID: PMC368149  PMID: 3437899

Abstract

We tested the effects of inhibitors of protein and RNA synthesis on the disaggregation-mediated destabilization of prespore mRNAs in Dictyostelium discoideum. Incubating disaggregated cells with daunomycin to inhibit RNA synthesis prevented the loss of prespore mRNAs, whereas the inhibitor decreased or did not affect levels of the common mRNAs CZ22 and actin. Protein synthesis inhibitors varied in their effects. Cycloheximide, which inhibited protein synthesis almost completely, prevented the loss of the prespore mRNAs, but puromycin, which inhibited protein synthesis less well, did not. These results indicate that the process of specific mRNA destabilization requires the synthesis of RNA and possibly of protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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