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. 1994 Jan;1(1):95–98. doi: 10.1128/cdli.1.1.95-98.1994

Immune response to bovine viral diarrhea virus induced by anti-idiotypic antibodies.

W Xue 1, H C Minocha 1
PMCID: PMC368203  PMID: 7496930

Abstract

We have previously prepared rabbit anti-idiotypic antibodies (anti-Ids) against the neutralizing monoclonal antibodies (MAbs) specific for the gp53 of bovine viral diarrhea virus (BVDV). The anti-Ids, purified by sequential immunoaffinity chromatography, inhibited the immunizing MAb from binding to the original antigens and blocked BVDV infection of cell cultures. This study evaluated immune responses in mice to the purified anti-Id reagents. BVDV-specific neutralizing antibodies were induced by the anti-Ids. The antisera (Ab3) induced by the anti-Ids immunoprecipitated gp53 from BVDV-infected Madin-Darby bovine kidney (MDBK) cell lysates. However, lymphocyte-proliferative responses were specific only for the respective immunizing antigens. These results suggest that the anti-Ids may bear an internal image of the gp53 to stimulate production of antibody but not to stimulate a virus-specific cellular immune response in mice.

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Selected References

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  1. Baker J. C. Bovine viral diarrhea virus: a review. J Am Vet Med Assoc. 1987 Jun 1;190(11):1449–1458. [PubMed] [Google Scholar]
  2. Bona C., Moran T. Idiotype vaccines. Ann Inst Pasteur Immunol. 1985 May-Jun;136C(3):299–312. doi: 10.1016/s0769-2625(85)80002-7. [DOI] [PubMed] [Google Scholar]
  3. Brownlie J. The pathogenesis of bovine virus diarrhoea virus infections. Rev Sci Tech. 1990 Mar;9(1):43–59. doi: 10.20506/rst.9.1.491. [DOI] [PubMed] [Google Scholar]
  4. Donahoe R. M., Peters R. L., VanVleck R., Huebner R. J., Kelloff G. J. Development of a lymphocyte transformation microassay for murine leukemia virus. J Natl Cancer Inst. 1976 Jan;56(1):51–57. doi: 10.1093/jnci/56.1.51. [DOI] [PubMed] [Google Scholar]
  5. Dulbecco R. Production of Plaques in Monolayer Tissue Cultures by Single Particles of an Animal Virus. Proc Natl Acad Sci U S A. 1952 Aug;38(8):747–752. doi: 10.1073/pnas.38.8.747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gaulton G. N., Sharpe A. H., Chang D. W., Fields B. N., Greene M. I. Syngeneic monoclonal internal image anti-idiotopes as prophylactic vaccines. J Immunol. 1986 Nov 1;137(9):2930–2936. [PubMed] [Google Scholar]
  7. Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
  8. Keay S., Rasmussen L., Merigan T. C. Syngeneic monoclonal anti-idiotype antibodies that bear the internal image of a human cytomegalovirus neutralization epitope. J Immunol. 1988 Feb 1;140(3):944–948. [PubMed] [Google Scholar]
  9. Kennedy R. C., Adler-Storthz K., Burns J. W., Sr, Henkel R. D., Dreesman G. R. Antiidiotype modulation of herpes simplex virus infection leading to increased pathogenicity. J Virol. 1984 Jun;50(3):951–953. doi: 10.1128/jvi.50.3.951-953.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kennedy R. C., Dreesman G. R. Immunoglobulin idiotypes: analysis of viral antigen-antibody systems. Prog Med Virol. 1985;31:168–182. [PubMed] [Google Scholar]
  11. Kennedy R. C., Melnick J. L., Dreesman G. R. Anti-idiotypes and immunity. Sci Am. 1986 Jul;255(1):48–56. doi: 10.1038/scientificamerican0786-48. [DOI] [PubMed] [Google Scholar]
  12. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680–685. doi: 10.1038/227680a0. [DOI] [PubMed] [Google Scholar]
  13. Lathey J. L., Courtney R. J., Rouse B. T. Production, binding characteristics, and immunogenicity of heterologous anti-idiotypic antibody to herpes simplex virus glycoprotein C. Viral Immunol. 1987 Spring;1(1):13–23. doi: 10.1089/vim.1987.1.13. [DOI] [PubMed] [Google Scholar]
  14. Maraskovsky E., Chen W. F., Shortman K. IL-2 and IFN-gamma are two necessary lymphokines in the development of cytolytic T cells. J Immunol. 1989 Aug 15;143(4):1210–1214. [PubMed] [Google Scholar]
  15. Marriott S. J., Roeder D. J., Consigli R. A. Anti-idiotypic antibodies to a polyomavirus monoclonal antibody recognize cell surface components of mouse kidney cells and prevent polyomavirus infection. J Virol. 1987 Sep;61(9):2747–2753. doi: 10.1128/jvi.61.9.2747-2753.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Onisk D. V., Donis R., Kelling C. L., Srikumaran S. Bovine viral diarrhea virus-specific neutralizing antibodies induced by anti-idiotypic antibodies. Viral Immunol. 1992 Winter;5(4):257–263. doi: 10.1089/vim.1992.5.257. [DOI] [PubMed] [Google Scholar]
  17. Orten D. J., Blecha F., Morrill J. L., Minocha H. C. Characterization of anti-idiotype reagents to bovine herpesvirus-1 monoclonal antibody. Vet Immunol Immunopathol. 1988 Dec;20(1):1–14. doi: 10.1016/0165-2427(88)90021-9. [DOI] [PubMed] [Google Scholar]
  18. Orten D. J., Reddy P. G., Reddy D. N., Xue W., Abdelmagid O. Y., Blecha F., Minocha H. C. Induction of immune response to bovine herpesvirus-1 with anti-idiotypic antibodies. Viral Immunol. 1991 Summer;4(2):111–122. doi: 10.1089/vim.1991.4.111. [DOI] [PubMed] [Google Scholar]
  19. Reagan K. J., Wunner W. H., Wiktor T. J., Koprowski H. Anti-idiotypic antibodies induce neutralizing antibodies to rabies virus glycoprotein. J Virol. 1983 Dec;48(3):660–666. doi: 10.1128/jvi.48.3.660-666.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Roth J. A., Kaeberle M. L. Suppression of neutrophil and lymphocyte function induced by a vaccinal strain of bovine viral diarrhea virus with and without the administration of ACTH. Am J Vet Res. 1983 Dec;44(12):2366–2372. [PubMed] [Google Scholar]
  21. Rouse B. T., Norley S., Martin S. Antiviral cytotoxic T lymphocyte induction and vaccination. Rev Infect Dis. 1988 Jan-Feb;10(1):16–33. doi: 10.1093/clinids/10.1.16. [DOI] [PubMed] [Google Scholar]
  22. Sharpe A. H., Gaulton G. N., McDade K. K., Fields B. N., Greene M. I. Syngeneic monoclonal antiidiotype can induce cellular immunity to reovirus. J Exp Med. 1984 Oct 1;160(4):1195–1205. doi: 10.1084/jem.160.4.1195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Tanaka M., Sasaki N., Seto A. Induction of antibodies against Newcastle disease virus with syngeneic anti-idiotype antibodies in mice. Microbiol Immunol. 1986;30(4):323–331. doi: 10.1111/j.1348-0421.1986.tb00949.x. [DOI] [PubMed] [Google Scholar]
  24. UytdeHaag F. G., Bunschoten H., Weijer K., Osterhaus A. D. From Jenner to Jerne: towards idiotype vaccines. Immunol Rev. 1986 Apr;90:93–113. doi: 10.1111/j.1600-065x.1986.tb01479.x. [DOI] [PubMed] [Google Scholar]
  25. Uytdehaag F. G., Osterhaus A. D. Induction of neutralizing antibody in mice against poliovirus type II with monoclonal anti-idiotypic antibody. J Immunol. 1985 Feb;134(2):1225–1229. [PubMed] [Google Scholar]
  26. Xue W., Blecha F., Minocha H. C. Antigenic variations in bovine viral diarrhea viruses detected by monoclonal antibodies. J Clin Microbiol. 1990 Aug;28(8):1688–1693. doi: 10.1128/jcm.28.8.1688-1693.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Xue W., Orten D. J., Abdelmagid O. Y., Rider M., Blecha F., Minocha H. C. Anti-idiotypic antibodies mimic bovine viral diarrhea virus antigen. Vet Microbiol. 1991 Nov;29(3-4):201–212. doi: 10.1016/0378-1135(91)90128-3. [DOI] [PubMed] [Google Scholar]
  28. Zhou E. M., Chanh T. C., Dreesman G. R., Kanda P., Kennedy R. C. Immune response to human immunodeficiency virus. In vivo administration of anti-idiotype induces an anti-gp160 response specific for a synthetic peptide. J Immunol. 1987 Nov 1;139(9):2950–2956. [PubMed] [Google Scholar]

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