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. 1994 Mar;1(2):241–243. doi: 10.1128/cdli.1.2.241-243.1994

Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis.

P Vannuffel 1, C Dieterich 1, B Naerhuyzen 1, P Gilot 1, M Coene 1, R Fiasse 1, C Cocito 1
PMCID: PMC368236  PMID: 7496954

Abstract

Sera from patients with Crohn's disease and control were analyzed by an enzyme-linked immunosorbent assay based on the Mycobacterium paratuberculosis-specific recombinant polypeptide a362. Anti-a362 immunoglobulin G (IgG) (P < 0.05) and IgA (P < 0.001) titers were higher in patients with Crohn's disease than in controls. A monomodal Gaussian distribution of anti-a362 IgA levels were found for controls, and a bimodal distribution was found for patients with Crohn's disease. An M. paratuberculosis etiology is suggested for the 36% of patients with Crohn's disease who had an anti-a362 IgA level higher than that of controls.

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Selected References

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