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. 1994 May;1(3):353–356. doi: 10.1128/cdli.1.3.353-356.1994

Analysis of tuberculous meningitis cases by an immunoblotting assay based on a mycobacterial antigen complex.

Y L Zou 1, M P Van Antwerpen 1, G Q Shi 1, Q X Chen 1, C J Sindic 1, C Cocito 1
PMCID: PMC368262  PMID: 7496976

Abstract

Tuberculous meningitis cases were analyzed by an immunoblotting test based on Mycobacterium bovis BCG antigen complex A60. Anti-A60 immunoglobulin G (IgG) in cerebrospinal fluid (CSF) allowed early diagnosis, and concentrations decreased after recovery. In primary meningitis forms, anti-A60 IgGs were intrathecally synthesized and specific oligoclonal IgGs were present in CSF. In meningeal complications of pulmonary tuberculosis, there were matching titers of anti-A60 IgG in blood and CSF (mirror pattern). Correlation between CSF-restricted patterns and CSF pleocytosis was shown.

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Selected References

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