The DOR is transported to the central terminals of sensory neurons in the spinal cord, independently of substance P.
(A) Immunoreactivity obtained with the anti-DOR antibody is lost in mice with a deletion of the ppt-A gene.
(B) Quantification of results in A.
(C) DOReGFP in the spinal cord is not altered in ppt-A null mice, indicating that DOR transport from the cell body to the central terminals of sensory neurons is independent of SP.
(D) Quantification of results in C.
(E, G) The binding pattern obtained with the DOR selective ligands, [125I]-DPDPE (E) and [125I]-deltorphin II (G), is not altered in ppt-A null mice.
(F, H) Quantification of results in E, G.
Results are expressed as mean ± SEM, n=8/group, *** p < 0.001.