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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Neuroimage. 2013 Apr 22;78:385–395. doi: 10.1016/j.neuroimage.2013.04.045

Fig. 5. Effects of intravascular susceptibility variation and hyperoxia challenge on extravascular water R1ρ.

Fig. 5

In order to detect the contribution of intravascular susceptibility changes to tissue R1ρ, the blood signal was suppressed with the injection of 5 mg/kg MION before experiments. Dynamic changes in tissue R2 and R1ρ were obtained during two injections of 1 mg/kg MION (A, n = 4 rats) and 3 minutes inhalation of 60% O2 (B, n = 5 rats) indicated by the yellow shaded regions. Time courses were obtained from the red pixels within the cortex (Inset). When spin-locking frequencies were measured at ≥500 Hz, a variation in intravascular susceptibility does not contribute to tissue R1ρ measurements.