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. 1984 Jan;4(1):216–220. doi: 10.1128/mcb.4.1.216

Multistep virus-induced leukemogenesis in vitro: description of a model specifying three steps within the myeloblastic malignant process.

J M Heard, S Fichelson, B Sola, M A Martial, B Varet, J P Levy
PMCID: PMC368679  PMID: 6583494

Abstract

A helper-independent Friend leukemia virus was used to infect bone marrow cultures. This virus induces myeloblastic leukemia in mice after a long latency period. Infection of the bone marrow cultures resulted in the in vitro production of myeloblastic leukemogenesis after a long latency period. Three steps were observed in the evolution of the infected cultures, and permanent cell lines were derived at each step. This allowed us to individualize three successive events in the course of the myeloblastic transformation: (i) an abnormal responsiveness to the physiological hormone granulo-macrophagic colony-stimulating factor, (ii) the acquisition of growth autonomy, and (iii) the acquisition of in vivo tumorigenicity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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