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. 1984 Feb;4(2):375–378. doi: 10.1128/mcb.4.2.375

Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes.

G Peters, C Kozak, C Dickson
PMCID: PMC368706  PMID: 6321961

Abstract

Two regions of mouse DNA which constitute common provirus integration sites in tumors induced by mouse mammary tumor virus have been identified and designated int-1 and int-2. By examining a series of hamster-mouse somatic cell hybrids, we mapped the int-2 locus to mouse chromosome 7 and confirmed the previous assignment of int-1 to chromosome 15. This constitutes proof that int-1 and int-2 are discrete genetic loci. It is therefore possible that proviral activation of two distinct cellular genes may result in the same neoplastic disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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