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. 1984 Mar;4(3):449–453. doi: 10.1128/mcb.4.3.449

Down-regulation of glucocorticoid receptors in mouse lymphoma cell variants.

M Danielsen, M R Stallcup
PMCID: PMC368722  PMID: 6546969

Abstract

The mouse thymoma-derived cell line W7 is sensitive to the cytolytic action of glucocorticoids. We have isolated a novel class of cell variant that apparently overcomes its inherent sensitivity to glucocorticoids by reversibly down-regulating the level of glucocorticoid receptors. This phenotype is stable during subcloning in the presence and in the absence of glucocorticoids and is dominant in somatic cell hybrids with wild-type cells. Fusion of this variant with wild-type cells produces hybrids that down-regulate and are less sensitive to glucocorticoids than hybrids of receptor-negative and wild-type cells. This is the first demonstration of a phenotypic change which correlates with down-regulation of the glucocorticoid receptor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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