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. 1984 Apr;4(4):809–812. doi: 10.1128/mcb.4.4.809

Spontaneous and 5-azacytidine-induced reexpression of ornithine carbamoyl transferase in hepatoma cells.

A Delers, J Szpirer, C Szpirer, D Saggioro
PMCID: PMC368801  PMID: 6201723

Abstract

Rat hepatoma cells that do not synthesize the hepatic enzyme ornithine carbamoyl transferase spontaneously give rise to producing cells at a low frequency. Reexpression of this differentiation trait is strongly increased by 5-azacytidine treatment, suggesting that hypermethylation plays a critical role in the impaired expression of the ornithine carbamoyl transferase gene in hepatoma cells.

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Selected References

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