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. Author manuscript; available in PMC: 2013 Jun 24.
Published in final edited form as: Vaccine. 2007 Mar 22;25(21):4183–4192. doi: 10.1016/j.vaccine.2007.03.008

Figure 5. VNP expressing anti-CEA scFv accumulate in CEA expressing intestinal cells and tumors in vivo.

Figure 5

Figure 5

Wild type (white bars) and CEA transgenic (black bars) mice were administered 108 cfu VNP, VNP/GS18, and VNP/GS18IND bacteria by oral gavage. The bars indicate the numbers of bacteria (cfu per gram of tissue) recovered 1 hour post intragastric inoculation from the upper small intestine (A) and lower small intestine (B) as described in Materials and Methods. (C) Mice were injected with 5 × 105 MC38 cells in the left flank and 5 × 105 MC38CEA cells in the right flank. Seven days later they received 106 cfu VNP/GS18IND. Tumors, liver and spleen were harvested for bacterial counts seven days later. Data are averages of two independent experiments. (A) *P < 0.05 vs wild mice; (C) *P < 0.01 vs MC38 tumor