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. 1985 Nov;5(11):3214–3221. doi: 10.1128/mcb.5.11.3214

Sequence-independent autoregulation of the adenovirus type 5 E1A transcription unit.

P Hearing, T Shenk
PMCID: PMC369137  PMID: 2943984

Abstract

The adenovirus E1A gene is known to be autoregulated at the level of transcription. Autoregulation was found to be mediated by products of the E1A 13S mRNA, which induced a fivefold increase in E1A transcription rate. Deletion analysis suggested that the autoregulation did not require any specific sequence in the E1A transcriptional control region. This conclusion was reinforced by the demonstration that a cellular alpha-globin gene substituted for the E1A gene on the adenovirus chromosome was also positively regulated by E1A gene products.

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Selected References

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