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. 1984 Dec;4(12):2925–2928. doi: 10.1128/mcb.4.12.2925

New rat cell line that is highly susceptible to transformation by several oncogenes.

E Liboi, M Caruso, C Basilico
PMCID: PMC369307  PMID: 6527690

Abstract

We describe here a new cell line, EL2, which spontaneously arose from primary rat embryo fibroblasts and has the distinctive property of being highly susceptible to a number of different transforming genes. The high susceptibility is expressed not only in high transformation frequencies but, most importantly, in an unusually high rate of growth of EL2 transformants under selective conditions, i.e., in soft agar or as foci. The biological characteristics of EL2 cells greatly accelerate the isolation of transformants from known oncogenes and could be useful to detect new transforming genes.

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Selected References

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